{"id":"W2901351136","doi":"10.1002/glia.23503","title":"Helper CD4 T cells expressing granzyme B cause glial fibrillary acidic protein fragmentation in astrocytes in an MHCII‐independent manner","year":2018,"lang":"en","type":"article","venue":"Glia","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital; Concordia University","funders":"Canadian Institutes of Health Research; Multiple Sclerosis Society of Canada","keywords":"Glial fibrillary acidic protein; Biology; Granzyme B; GFAP stain; Astrocyte; Neuroglia; Fragmentation (computing); Cell biology; Immunology; Neuroscience; Immune system; CD8; Central nervous system; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002091972,0.000197594,0.0001842328,0.0001742913,0.0001417843,0.0001025612,0.0002412769,0.00009727249,0.000160255],"category_scores_gemma":[0.00005881489,0.0001938222,0.00004193851,0.0002431794,0.0001535875,0.000673178,0.0000878201,0.0002208812,0.0001461764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008432515,"about_ca_system_score_gemma":0.00004602073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001268679,"about_ca_topic_score_gemma":0.0002780698,"domain_scores_codex":[0.9979345,0.0002370697,0.0003532541,0.0005913173,0.0004256555,0.0004582279],"domain_scores_gemma":[0.9994782,0.00004599403,0.0001096856,0.0002407266,0.00002743792,0.00009791071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001801893,0.00007076511,0.00291716,0.00001364411,8.821741e-7,0.0001437589,0.0007370432,0.0001483136,0.9951419,0.00005022419,0.00005204247,0.0005441163],"study_design_scores_gemma":[0.0007702771,0.0002361607,0.004456594,0.000125377,0.000003358321,0.000009118326,0.0001445258,0.0007253345,0.9929385,0.0001445511,0.0002366346,0.0002096006],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987817,0.0000450373,0.0001449457,0.00007788358,0.0002721693,0.0004325768,0.00000995201,0.00005337371,0.0001823468],"genre_scores_gemma":[0.9986826,0.000008216683,0.000267242,0.0004705738,0.0003067187,0.00004429038,0.000003815584,0.00002838179,0.000188194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002203393,"threshold_uncertainty_score":0.7903838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04339633515640267,"score_gpt":0.2968888472689653,"score_spread":0.2534925121125626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}