{"id":"W2901351136","doi":"10.1002/glia.23503","title":"Helper CD4 T cells expressing granzyme B cause glial fibrillary acidic protein fragmentation in astrocytes in an MHCII‐independent manner","year":2018,"lang":"en","type":"article","venue":"Glia","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital; Concordia University","funders":"Canadian Institutes of Health Research; Multiple Sclerosis Society of Canada","keywords":"Glial fibrillary acidic protein; Biology; Granzyme B; GFAP stain; Astrocyte; Neuroglia; Fragmentation (computing); Cell biology; Immunology; Neuroscience; Immune system; CD8; Central nervous system; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000180404,0.000617018,0.0003021864,0.0002004631,0.0001660231,0.0002452591,0.000203934,0.0004712339,0.001265894],"category_scores_gemma":[0.0001357107,0.0002158459,0.000363025,0.0001274874,0.0002821053,0.0001989893,0.0002636525,0.0009088299,0.0005162213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002004308,"about_ca_system_score_gemma":0.0001308839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000331753,"about_ca_topic_score_gemma":0.0003127401,"domain_scores_codex":[0.9997516,0.00003458714,0.00002495803,0.00004542572,0.0000483593,0.00009504932],"domain_scores_gemma":[0.9997856,0.00004433957,0.00004786467,0.00004511881,0.00002647142,0.00005062145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001299268,0.00003348191,0.00008966702,0.00002634939,0.000003351623,0.00007741223,0.00001754421,0.00002166404,0.999207,0.00002477655,0.00001646301,0.0003524818],"study_design_scores_gemma":[0.00007327685,0.001078908,0.003053302,0.000007616618,0.00002209757,0.0005538835,0.00006611468,0.0007586446,0.993196,0.00007654078,0.001109553,0.000003988252],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949505,0.0006607565,0.002878327,0.0000556461,0.00005864198,0.00004478028,0.0001556884,0.00009457897,0.001101102],"genre_scores_gemma":[0.9942953,0.0004498873,0.002115111,0.00007548452,0.00002581339,0.0000659283,0.0003422185,0.00002496055,0.002605276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001265894,"threshold_uncertainty_score":0.004234791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04339633515640267,"score_gpt":0.2968888472689653,"score_spread":0.2534925121125626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}