{"id":"W2901361006","doi":"10.1038/s41598-018-35603-0","title":"Genome-wide DNA methylation changes in CD19+ B cells from relapsing-remitting multiple sclerosis patients","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Multiple Sclerosis Australia","keywords":"DNA methylation; Epigenetics; Lymphotoxin alpha; Multiple sclerosis; Biology; Methylation; Epigenome; Genetics; Gene; Cancer research; Immunology; Gene expression; Lymphotoxin; Cytokine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009983974,0.0001523144,0.0002115039,0.0005291193,0.0002392939,0.0002375415,0.0001127918,0.0001968499,0.002232261],"category_scores_gemma":[0.000287974,0.00009513191,0.0001343989,0.000321557,0.00008766536,0.00006586314,0.0001549032,0.0001784851,0.0002852301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001249371,"about_ca_system_score_gemma":0.00006492717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001980513,"about_ca_topic_score_gemma":0.002205398,"domain_scores_codex":[0.9998978,0.00001574488,0.00001104829,0.00003947943,0.00002054244,0.00001539306],"domain_scores_gemma":[0.9999058,0.00001656738,0.00002790851,0.000007542671,0.00002157504,0.00002056189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002318771,0.00009543911,0.7680416,0.0001080036,0.0003394284,0.0004579928,0.0004011299,0.0001804186,0.2044635,0.00004263688,0.0005605319,0.02299053],"study_design_scores_gemma":[0.00001738748,0.0001795757,0.9924605,0.00000411662,0.00006713075,0.0007461071,0.00009627129,0.0001152784,0.005561855,0.0000295633,0.0007186336,0.000003482839],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979814,0.000554355,0.0002211839,0.00003297625,0.000004778911,0.000007467619,0.000831129,0.00001028755,0.0003564293],"genre_scores_gemma":[0.9982924,0.0001791461,0.0001780585,0.00003328093,0.000005478749,0.00001155678,0.0008230093,0.000004264389,0.0004727547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002232261,"threshold_uncertainty_score":0.007467628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02032684715445179,"score_gpt":0.2306587802906026,"score_spread":0.2103319331361508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}