{"id":"W2901363487","doi":"10.1136/annrheumdis-2018-eular.4877","title":"FRI0339 Sledai-2k responder index-50 is effective in demonstrating partial response in a phase 2, randomised placebo-controlled study of ustekinumab in patients with active systemic lupus erythematosus","year":2018,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Krembil Foundation","funders":"Janssen Research and Development","keywords":"Medicine; Ustekinumab; Internal medicine; Randomized controlled trial; Placebo; Gastroenterology; Immunology; Disease; Adalimumab; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002406333,0.001628156,0.003460193,0.0006689264,0.0005487522,0.001236877,0.00120144,0.002016203,0.00632146],"category_scores_gemma":[0.001669531,0.0009076655,0.001785748,0.0004223599,0.001502437,0.001358907,0.0003887684,0.004271655,0.001219601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007233829,"about_ca_system_score_gemma":0.0008430933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001030285,"about_ca_topic_score_gemma":0.00291943,"domain_scores_codex":[0.9991397,0.0004327297,0.00005569222,0.0001206112,0.000074253,0.0001770357],"domain_scores_gemma":[0.9990531,0.0003223328,0.0001526442,0.00006887495,0.00004116709,0.0003618107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9411628,0.01135426,0.0009201991,0.000769606,0.00121711,0.0001000922,0.0001314105,0.0004125722,0.009454889,0.000136367,0.001044091,0.03329669],"study_design_scores_gemma":[0.8593742,0.1333109,0.004790233,0.00003412546,0.0004413247,0.00008153882,0.00004732563,0.0004442807,0.0007904239,0.00009080002,0.0005665508,0.00002837917],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902301,0.004989488,0.000415319,0.0005227153,0.0003076606,0.001022108,0.0004592447,0.0002084161,0.001844937],"genre_scores_gemma":[0.9941367,0.001811105,0.0006354669,0.0006109696,0.000238245,0.0006802137,0.0004444207,0.00002558889,0.001417438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00632146,"threshold_uncertainty_score":0.02114737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02134386317571131,"score_gpt":0.3343934531506148,"score_spread":0.3130495899749035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}