{"id":"W2901395960","doi":"10.1021/acs.nanolett.8b03601","title":"Interrogation of Antigen Display on Individual Vaccine Nanoparticles for Achieving Neutralizing Antibody Responses against Hepatitis C Virus","year":2018,"lang":"en","type":"article","venue":"Nano Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Division of Chemical, Bioengineering, Environmental, and Transport Systems; National Institute of Biomedical Imaging and Bioengineering; National Institute of Allergy and Infectious Diseases; U.S. Department of Defense; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Alberta Emerald Foundation","keywords":"Neutralizing antibody; Antibody; Virology; Epitope; Antigen; In vivo; Chemistry; Biology; Virus; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002366655,0.0003054304,0.0001970529,0.0001843856,0.0001266999,0.0003627545,0.0001436382,0.0004564718,0.0005459496],"category_scores_gemma":[0.0002607728,0.0001746479,0.0001204834,0.0001107393,0.0001855312,0.0003186107,0.0002064048,0.000251732,0.000217464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002940687,"about_ca_system_score_gemma":0.0001160829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002610999,"about_ca_topic_score_gemma":0.0004178942,"domain_scores_codex":[0.9998757,0.00002260804,0.000006959613,0.00003055876,0.00003536241,0.00002881899],"domain_scores_gemma":[0.9999247,0.00002362626,0.0000167762,0.000007954393,0.00001783935,0.000009073839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001786113,0.000008764346,0.00008951074,0.00001109993,0.000001474369,0.000006794616,0.000006264844,0.0001417753,0.9987036,0.00004800975,0.000009844936,0.0009550015],"study_design_scores_gemma":[0.0000030304,0.00009250618,0.0006348763,0.000001246497,0.000003318633,0.00003040359,0.000009396899,0.002626611,0.9961999,0.00002705555,0.000369209,0.000002420843],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882317,0.0003337403,0.01038506,0.0000406429,0.00001123306,0.00002917075,0.00005799229,0.00004866081,0.0008617034],"genre_scores_gemma":[0.9902537,0.0003424162,0.008436808,0.00004254525,0.000005341913,0.00002985393,0.00007629723,0.00001487431,0.0007980625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005459496,"threshold_uncertainty_score":0.002133667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04584691789224967,"score_gpt":0.3697135363440647,"score_spread":0.323866618451815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}