{"id":"W2901409674","doi":"10.1111/jphp.13045","title":"Effect of an anxiolytic botanical containing <i>Souroubea sympetala</i> and <i>Platanus occidentalis</i> on <i>in-vitro</i> diazepam human cytochrome P450-mediated metabolism","year":2018,"lang":"en","type":"article","venue":"Journal of Pharmacy and Pharmacology","topic":"Natural product bioactivities and synthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Public Health; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Betulinic acid; Cytochrome P450; Lupeol; Diazepam; Pharmacology; CYP3A4; Metabolite; Chemistry; Anxiolytic; CYP1A2; Drug metabolism; CYP2C9; Metabolism; Microsome; Natural product; Ursolic acid; Biochemistry; Biology; Chromatography; In vitro; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005386773,0.0002947527,0.0002170426,0.0002146076,0.0001473466,0.0001467364,0.0001070765,0.0001845891,0.00205089],"category_scores_gemma":[0.0001159416,0.00008053695,0.0002639883,0.0001517428,0.0001229255,0.0001279389,0.0001401831,0.0002989449,0.0001759129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000826742,"about_ca_system_score_gemma":0.000135449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006785972,"about_ca_topic_score_gemma":0.001297777,"domain_scores_codex":[0.9999647,0.00000947007,0.000002736963,0.00000763758,0.000007123571,0.000008231201],"domain_scores_gemma":[0.9999334,0.00001799156,0.00001801642,0.000004075945,0.000008833502,0.00001774668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003218946,0.0005437154,0.0006559674,0.00026053,0.00006473863,0.0001457203,0.00004157205,0.00009556388,0.9842042,0.00004487369,0.00009701141,0.01062708],"study_design_scores_gemma":[0.0002948822,0.01992014,0.03410242,0.00005909815,0.0004090786,0.0006068173,0.0002070699,0.0007195757,0.9398003,0.00007152207,0.003785486,0.00002355556],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970738,0.001524757,0.0002002468,0.00005674737,0.00001758067,0.00001652645,0.0001364419,0.00001533183,0.0009585453],"genre_scores_gemma":[0.9968495,0.001231606,0.0006184707,0.00008497653,0.00001454473,0.00001401961,0.0001943886,0.00000459313,0.0009879473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00205089,"threshold_uncertainty_score":0.006860852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007976072605074824,"score_gpt":0.308800209131469,"score_spread":0.3008241365263942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}