{"id":"W2901409674","doi":"10.1111/jphp.13045","title":"Effect of an anxiolytic botanical containing <i>Souroubea sympetala</i> and <i>Platanus occidentalis</i> on <i>in-vitro</i> diazepam human cytochrome P450-mediated metabolism","year":2018,"lang":"en","type":"article","venue":"Journal of Pharmacy and Pharmacology","topic":"Natural product bioactivities and synthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Public Health; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Betulinic acid; Cytochrome P450; Lupeol; Diazepam; Pharmacology; CYP3A4; Metabolite; Chemistry; Anxiolytic; CYP1A2; Drug metabolism; CYP2C9; Metabolism; Microsome; Natural product; Ursolic acid; Biochemistry; Biology; Chromatography; In vitro; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001059018,0.0002724499,0.0006083227,0.0001360778,0.0001093939,0.00002354579,0.0002228989,0.0001251129,0.00004036483],"category_scores_gemma":[0.0000837494,0.0002170193,0.0001254286,0.0001293153,0.0003864352,0.00004295529,0.0001090576,0.0003733546,0.000001157751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001886758,"about_ca_system_score_gemma":0.00004258927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002857777,"about_ca_topic_score_gemma":0.00000416562,"domain_scores_codex":[0.9980208,0.0005668193,0.000563436,0.0003359895,0.0001824631,0.0003304426],"domain_scores_gemma":[0.9989086,0.000229674,0.0004037365,0.0001343255,0.00009817688,0.0002254977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008071004,0.0001520069,0.0009026579,0.00005117041,0.0001978365,0.00007783485,0.00008692803,0.000002549173,0.9853666,0.000005789442,0.0003406033,0.004744956],"study_design_scores_gemma":[0.006016832,0.003241479,0.001725651,0.00002271144,0.0002889302,0.0003733921,0.00003399849,0.00005387604,0.9827285,0.00001300326,0.005289854,0.0002118205],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960646,0.00287627,0.000003039073,0.0002402587,0.0004171075,0.0002198904,0.00005117906,0.000005495884,0.0001221708],"genre_scores_gemma":[0.9969056,0.0006986356,0.00004075117,0.000979021,0.001306179,0.000005239074,0.00002020985,0.00002531087,0.00001910003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004949251,"threshold_uncertainty_score":0.884979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007976072605074824,"score_gpt":0.308800209131469,"score_spread":0.3008241365263942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}