{"id":"W2901440309","doi":"10.1371/journal.pgen.1007788","title":"Single-cell RNA-sequencing reveals transcriptional dynamics of estrogen-induced dysplasia in the ovarian surface epithelium","year":2018,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Ottawa Hospital Research Institute; Canadian Institutes of Health Research; University of Ottawa","keywords":"Biology; Ovarian cancer; Cell; Cancer research; Population; Epithelium; Estrogen; Cell growth; Cell biology; Cancer; Endocrinology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003137334,0.0002468818,0.0002403194,0.00005256177,0.00009459215,0.00003274328,0.0005026151,0.0002575839,0.00002214721],"category_scores_gemma":[0.00003903718,0.0002175542,0.0001264359,0.0002037999,0.0001866337,0.000005243127,0.00003849037,0.000182873,0.000008349974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006199979,"about_ca_system_score_gemma":0.0001530825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003581456,"about_ca_topic_score_gemma":0.0003542837,"domain_scores_codex":[0.9982804,0.0001667278,0.0004778552,0.0003891537,0.0003046917,0.0003811927],"domain_scores_gemma":[0.9990473,0.00003507738,0.0001420125,0.0005141807,0.0001864581,0.00007500833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008714062,0.0003012599,0.004935419,0.00004688454,0.0000390969,0.000003931818,0.0004958372,0.000178637,0.9933397,0.0002542915,0.00003637625,0.0002814865],"study_design_scores_gemma":[0.0007757138,0.0008241794,0.0007430674,0.00003715486,0.00005989833,0.0000166473,0.0002796667,0.004423734,0.9918164,0.0002671208,0.0004901333,0.0002662728],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953814,0.0004747477,0.001426136,0.0001968673,0.0002987032,0.0003127501,0.00007867614,0.00001141039,0.001819324],"genre_scores_gemma":[0.9954263,0.00008223241,0.003618551,0.0002666978,0.0003540347,0.000007796804,0.0001056068,0.00004546119,0.00009334507],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004245097,"threshold_uncertainty_score":0.8871604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03198924896882779,"score_gpt":0.2324130495838295,"score_spread":0.2004238006150017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}