{"id":"W2901458579","doi":"10.1016/j.scr.2018.11.005","title":"Induction of rod versus cone photoreceptor-specific progenitors from retinal precursor cells","year":2018,"lang":"en","type":"article","venue":"Stem Cell Research","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont; University of Toronto; University Health Network; Canada Research Chairs; McMaster University","funders":"Canadian Institutes of Health Research; National Institutes of Health; Ontario Institute for Regenerative Medicine; National Eye Institute; Ontario Research Foundation","keywords":"Biology; Progenitor cell; Cell biology; Progenitor; Lineage (genetic); Stem cell; Retinal; Cellular differentiation; Cell fate determination; Multipotent Stem Cell; Embryonic stem cell; Immunology; Genetics; Transcription factor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004990362,0.0001283868,0.0001296167,0.00009132623,0.0001242719,0.00002905103,0.0002788645,0.0001790593,0.0003076893],"category_scores_gemma":[0.00001827452,0.0001222101,0.00006245651,0.0002385862,0.0003835963,0.000005369929,0.0001471074,0.0001682087,0.0002123813],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003144826,"about_ca_system_score_gemma":0.0001678255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005755609,"about_ca_topic_score_gemma":0.00002109359,"domain_scores_codex":[0.9983136,0.0001918233,0.0002244327,0.0004258387,0.0004812295,0.0003630627],"domain_scores_gemma":[0.9990038,0.00004357697,0.00007356104,0.0003284787,0.0004472034,0.0001034202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001727987,0.00008253488,0.001097323,0.00002267212,0.0000292956,0.000001014058,0.0002354708,3.386935e-7,0.9753664,0.00001279691,0.01649707,0.004927109],"study_design_scores_gemma":[0.0008235969,0.0009376968,0.0006063547,0.0000143181,0.000004143551,3.200418e-7,0.0007893648,0.000003128459,0.8852521,0.00002194938,0.1114249,0.0001221967],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9784119,0.000791157,0.00003805453,0.00002909101,0.000705615,0.0003532585,0.000018696,0.000008578774,0.01964363],"genre_scores_gemma":[0.9948801,0.0003798104,0.0004567635,0.000003673137,0.0005377524,0.00003094347,0.0001033689,0.00002341343,0.003584187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09492779,"threshold_uncertainty_score":0.4983585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05292973273348828,"score_gpt":0.3177235232304745,"score_spread":0.2647937904969862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}