{"id":"W2901464794","doi":"10.1042/bcj20180795","title":"Camelid single-domain antibodies raised by DNA immunization are potent inhibitors of EGFR signaling","year":2018,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; University of Ottawa; National Research Council Canada","funders":"National Research Council Canada","keywords":"Epitope; Cetuximab; Biology; Single-domain antibody; Ectodomain; Epitope mapping; Antibody; Epidermal growth factor receptor; Molecular biology; Monoclonal antibody; Receptor; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003186714,0.0001781673,0.0003609439,0.0001384216,0.0001806668,0.00003650889,0.0001657364,0.000141248,0.0002828084],"category_scores_gemma":[0.0002422812,0.0001341446,0.0001887524,0.000236421,0.0004422869,0.00006682622,0.00009602548,0.0003814111,0.00002563502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009323927,"about_ca_system_score_gemma":0.00009621184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000182389,"about_ca_topic_score_gemma":4.699076e-7,"domain_scores_codex":[0.9981797,0.0000773833,0.0005260384,0.0001921597,0.0006555608,0.0003691755],"domain_scores_gemma":[0.9986637,0.00007577952,0.0002551694,0.0001536548,0.0005556899,0.0002960404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005766761,0.0002632982,0.00819232,0.00007389596,0.00009630216,0.0000365482,0.0001890557,3.510559e-7,0.9658406,0.00001663988,0.02356623,0.001148097],"study_design_scores_gemma":[0.001033254,0.0005250736,0.001856273,0.0005103509,0.00003200334,0.0003571098,0.0003744769,0.00003258541,0.9886191,0.0001705451,0.006340219,0.0001489727],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939049,0.00196103,0.0003670578,0.002483471,0.0001877496,0.0001244459,0.00002546275,0.00001908795,0.0009267926],"genre_scores_gemma":[0.9962521,0.0002084927,0.001666772,0.000253297,0.001161068,0.00000129151,0.00004557273,0.00002363574,0.0003877785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02277855,"threshold_uncertainty_score":0.5470258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02017624596829532,"score_gpt":0.2839313773214005,"score_spread":0.2637551313531052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}