{"id":"W2901464794","doi":"10.1042/bcj20180795","title":"Camelid single-domain antibodies raised by DNA immunization are potent inhibitors of EGFR signaling","year":2018,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; University of Ottawa; National Research Council Canada","funders":"National Research Council Canada","keywords":"Epitope; Cetuximab; Biology; Single-domain antibody; Ectodomain; Epitope mapping; Antibody; Epidermal growth factor receptor; Molecular biology; Monoclonal antibody; Receptor; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002581922,0.0005088031,0.0003276974,0.0004141079,0.0001307798,0.0003009969,0.0003230741,0.0005693253,0.001391822],"category_scores_gemma":[0.0002005071,0.0001769654,0.0004344172,0.0001493274,0.0002211187,0.0002169286,0.0002313513,0.0007729793,0.0007372494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003768586,"about_ca_system_score_gemma":0.00009428119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000132185,"about_ca_topic_score_gemma":0.0001688473,"domain_scores_codex":[0.9997688,0.00004022531,0.00002320574,0.0000572968,0.00005669,0.00005368402],"domain_scores_gemma":[0.9998518,0.00003433759,0.00004212161,0.00001963759,0.00002662128,0.00002546988],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003387894,0.00002495357,0.00009134873,0.00002629685,0.000006299289,0.00002537319,0.000005424871,0.00002972943,0.9987658,0.00004359781,0.00006322029,0.0008839658],"study_design_scores_gemma":[0.00003399401,0.0004605695,0.001616606,0.000006220537,0.00002462005,0.0003283641,0.000005535294,0.0003916149,0.9921428,0.00002565159,0.004960483,0.000003632857],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9684787,0.003291262,0.02235019,0.0003500487,0.0001787438,0.0002534334,0.001130696,0.0003764417,0.003590549],"genre_scores_gemma":[0.9807976,0.001398501,0.01005066,0.0004169949,0.0001107354,0.000184877,0.00272798,0.00005331252,0.004259321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001391822,"threshold_uncertainty_score":0.004656136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02017624596829532,"score_gpt":0.2839313773214005,"score_spread":0.2637551313531052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}