{"id":"W2901523494","doi":"10.1007/s40257-018-0396-z","title":"Improvement in Patient-Reported Outcomes (Dermatology Life Quality Index and the Psoriasis Symptoms and Signs Diary) with Guselkumab in Moderate-to-Severe Plaque Psoriasis: Results from the Phase III VOYAGE 1 and VOYAGE 2 Studies","year":2018,"lang":"en","type":"article","venue":"American Journal of Clinical Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research","funders":"Janssen Research and Development; Janssen Scientific Affairs","keywords":"Dermatology Life Quality Index; Medicine; Adalimumab; Psoriasis; Psoriasis Area and Severity Index; Placebo; Quality of life (healthcare); Internal medicine; Minimal clinically important difference; Dermatology; Randomized controlled trial; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.001679763,0.0004188465,0.002409379,0.0002019263,0.0002382849,0.0000320207,0.0003018354,0.0002839215,0.00001130385],"category_scores_gemma":[0.002675504,0.0002185787,0.0001433752,0.0002956759,0.003300952,0.0001505541,0.0002506867,0.000676181,0.000004266109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003026747,"about_ca_system_score_gemma":0.0002190679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001136034,"about_ca_topic_score_gemma":0.001447097,"domain_scores_codex":[0.9925611,0.003338287,0.002884531,0.000586563,0.0001230104,0.0005064946],"domain_scores_gemma":[0.9874306,0.009911392,0.001835668,0.0004548833,0.0002259215,0.0001415911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.09820367,0.001145346,0.7102587,0.00002157228,0.00672883,0.0008101888,0.01589585,0.00001056201,0.000280075,0.000323288,0.001001545,0.1653204],"study_design_scores_gemma":[0.2461692,0.009188466,0.7043853,0.0003426085,0.001835043,0.003927455,0.0261067,0.0001126795,0.001914179,0.001734266,0.003084304,0.001199729],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844027,0.002782299,0.00009614873,0.01143515,0.0006043302,0.0005588081,0.00007174758,0.00001527089,0.000033614],"genre_scores_gemma":[0.9947069,0.001972725,0.0001210511,0.003039806,0.00006762385,0.00004117499,0.00001406571,0.00002094966,0.00001566138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1641207,"threshold_uncertainty_score":0.9994115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03698518268949746,"score_gpt":0.3453962599857336,"score_spread":0.3084110772962362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}