{"id":"W2901523494","doi":"10.1007/s40257-018-0396-z","title":"Improvement in Patient-Reported Outcomes (Dermatology Life Quality Index and the Psoriasis Symptoms and Signs Diary) with Guselkumab in Moderate-to-Severe Plaque Psoriasis: Results from the Phase III VOYAGE 1 and VOYAGE 2 Studies","year":2018,"lang":"en","type":"article","venue":"American Journal of Clinical Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research","funders":"Janssen Research and Development; Janssen Scientific Affairs","keywords":"Dermatology Life Quality Index; Medicine; Adalimumab; Psoriasis; Psoriasis Area and Severity Index; Placebo; Quality of life (healthcare); Internal medicine; Minimal clinically important difference; Dermatology; Randomized controlled trial; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007192449,0.000640386,0.002205322,0.0003835683,0.0002107066,0.0007619028,0.0004890882,0.0005783938,0.000886092],"category_scores_gemma":[0.003030199,0.0003005149,0.002874463,0.0005130346,0.0004314643,0.000486862,0.0003862033,0.001162629,0.0001365153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003702966,"about_ca_system_score_gemma":0.000454014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003057661,"about_ca_topic_score_gemma":0.0008680244,"domain_scores_codex":[0.9979001,0.00136345,0.0001736007,0.0001883976,0.0002673072,0.0001071487],"domain_scores_gemma":[0.9970829,0.001126465,0.001150376,0.0001981011,0.0001789995,0.0002632257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6577516,0.007347769,0.0889206,0.004234123,0.02591598,0.00006892381,0.0002966559,0.001613887,0.01967194,0.00009917864,0.00180395,0.1922756],"study_design_scores_gemma":[0.2014344,0.2966909,0.4700035,0.0006093417,0.01798655,0.0004920197,0.0001737977,0.001474358,0.007142835,0.0002635625,0.003645995,0.00008272821],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9694391,0.02819563,0.0005693597,0.0001648886,0.00006145145,0.0002853124,0.0004565696,0.00003347522,0.0007942203],"genre_scores_gemma":[0.9945589,0.00377882,0.0005321116,0.0001971818,0.00006834947,0.0002054892,0.0004630649,0.000008903335,0.0001871614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007192449,"threshold_uncertainty_score":0.03803778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03698518268949746,"score_gpt":0.3453962599857336,"score_spread":0.3084110772962362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}