{"id":"W2901569771","doi":"10.1016/j.sbi.2018.11.002","title":"PARP family enzymes: regulation and catalysis of the poly(ADP-ribose) posttranslational modification","year":2018,"lang":"en","type":"review","venue":"Current Opinion in Structural Biology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":191,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Poly ADP ribose polymerase; Ribose; Enzyme; Biology; Cell biology; Biochemistry; Transcription (linguistics); Polymerase; DNA; DNA repair; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005351703,0.0007747547,0.0009670158,0.000695042,0.0002091962,0.001042075,0.0009782815,0.001054339,0.003421483],"category_scores_gemma":[0.0004605695,0.0002382562,0.0003913702,0.001186848,0.0005955719,0.001414617,0.0007509721,0.001915187,0.002943048],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005954076,"about_ca_system_score_gemma":0.0007482536,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004058995,"about_ca_topic_score_gemma":0.00063815,"domain_scores_codex":[0.9998438,0.00002238514,0.00001557426,0.00003161613,0.00006426292,0.00002222931],"domain_scores_gemma":[0.9997903,0.00007282636,0.0000535586,0.000008246616,0.00004940416,0.00002577334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001394781,0.00005683233,0.000197834,0.00910824,0.00009798622,0.0002767543,0.00004677339,0.0006545545,0.00806656,0.007379835,0.02840979,0.9455653],"study_design_scores_gemma":[0.00002376772,0.00008180716,0.0005522824,0.0008851865,0.00006407483,0.001081884,0.00004270287,0.0001741665,0.002880939,0.003807247,0.9903845,0.0000214318],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002610786,0.9963407,0.0007010291,0.0007906218,0.0003975818,0.000006161345,0.00003546265,0.00001340387,0.00145399],"genre_scores_gemma":[0.001933301,0.9959087,0.0004291476,0.0003058772,0.0003347586,0.000007344009,0.00008539369,0.000002207085,0.000993204],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003421483,"threshold_uncertainty_score":0.011446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1693165092158756,"score_gpt":0.4498574468977701,"score_spread":0.2805409376818945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}