{"id":"W2901601525","doi":"10.1158/2326-6066.cir-18-0136","title":"Peripheral Blood TCR Repertoire Profiling May Facilitate Patient Stratification for Immunotherapy against Melanoma","year":2018,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":164,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Universität Zürich; Bristol-Myers Squibb Canada; Bristol-Myers Squibb","keywords":"Melanoma; Immunotherapy; T-cell receptor; Medicine; Blockade; Oncology; Immunology; Exact test; Internal medicine; Peripheral blood mononuclear cell; Proportional hazards model; Immune system; Cancer research; T cell; Biology; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006881757,0.0003909794,0.0003716318,0.0008468977,0.0001570259,0.0006176358,0.0001208674,0.0003144616,0.001941273],"category_scores_gemma":[0.00160364,0.0001132415,0.0001282629,0.000421004,0.00009869465,0.0002787099,0.0002821263,0.000396115,0.0004758631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001110277,"about_ca_system_score_gemma":0.00007980844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000219193,"about_ca_topic_score_gemma":0.0004248417,"domain_scores_codex":[0.999801,0.00007186339,0.00002741924,0.00004283811,0.00003058207,0.00002627439],"domain_scores_gemma":[0.9992434,0.0003604444,0.0001825179,0.00004717256,0.00008463838,0.00008178445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00186032,0.0001356314,0.8812932,0.00007834929,0.00005791601,0.0002733804,0.00006728595,0.0008704996,0.05446278,0.000112132,0.0007114809,0.06007703],"study_design_scores_gemma":[0.00004871788,0.001156182,0.9619969,0.00007830194,0.0001040726,0.002108313,0.000201536,0.01357236,0.01630368,0.0007448903,0.003666465,0.00001867478],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933732,0.001353959,0.003011012,0.0001327638,0.0000220312,0.00003409022,0.0005248641,0.00006726076,0.001480873],"genre_scores_gemma":[0.9968941,0.0002307772,0.002080037,0.00008832673,0.00002505664,0.00002045005,0.0003176951,0.000005939431,0.0003376758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001941273,"threshold_uncertainty_score":0.006494164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08599289826017605,"score_gpt":0.3826656564182738,"score_spread":0.2966727581580977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}