{"id":"W2901604060","doi":"10.1186/s12915-018-0607-3","title":"Evolution of mitochondrial TAT translocases illustrates the loss of bacterial protein transport machines in mitochondria","year":2018,"lang":"en","type":"article","venue":"BMC Biology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"European Regional Development Fund; Wissenschaftskolleg zu Berlin; Grantová Agentura, Univerzita Karlova; Biotechnology and Biological Sciences Research Council; Univerzita Karlova v Praze; Grantová Agentura České Republiky; Ministerstvo Školství, Mládeže a Tělovýchovy","keywords":"Biology; Translocase; Translocase of the inner membrane; Twin-arginine translocation pathway; Inner membrane; Mitochondrion; Transport protein; Cell biology; Mitochondrial membrane transport protein; Intermembrane space; Membrane transport protein; Biochemistry; Membrane protein; Bacterial outer membrane; Inner mitochondrial membrane; Gene; Escherichia coli; Membrane; Chromosomal translocation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002089285,0.0002752741,0.0002205019,0.0004973562,0.00039,0.0007680763,0.0003063497,0.000653053,0.0004287842],"category_scores_gemma":[0.0003165105,0.000156726,0.0002792871,0.0004977249,0.0004763687,0.0004670506,0.0007544948,0.0007370376,0.0004624788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008169121,"about_ca_system_score_gemma":0.0003303637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000597104,"about_ca_topic_score_gemma":0.0004924867,"domain_scores_codex":[0.9998287,0.00001867198,0.00001790339,0.00005295394,0.00004158492,0.00004017347],"domain_scores_gemma":[0.9996705,0.00005170788,0.0001070292,0.00004595561,0.00005772332,0.0000671736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002490108,0.00003180305,0.008711006,0.0001088497,0.00001447886,0.0004212186,0.0001704209,0.0003422909,0.9810711,0.001431134,0.0000368957,0.007411786],"study_design_scores_gemma":[0.00003120087,0.0004844773,0.1708817,0.00009072072,0.0001301286,0.007894957,0.0006014635,0.005094877,0.7848149,0.002382786,0.02751851,0.0000743429],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930386,0.001238757,0.003792586,0.0001113691,0.00001455361,0.00001175275,0.0001779037,0.00006474871,0.001549784],"genre_scores_gemma":[0.9951771,0.0006278957,0.003060763,0.00002922934,0.000006978541,0.000009538245,0.0003139006,0.00002170461,0.0007528916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008169121,"threshold_uncertainty_score":0.005927145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01331709846507915,"score_gpt":0.2512493971546438,"score_spread":0.2379322986895647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}