{"id":"W2901604060","doi":"10.1186/s12915-018-0607-3","title":"Evolution of mitochondrial TAT translocases illustrates the loss of bacterial protein transport machines in mitochondria","year":2018,"lang":"en","type":"article","venue":"BMC Biology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"European Regional Development Fund; Wissenschaftskolleg zu Berlin; Grantová Agentura, Univerzita Karlova; Biotechnology and Biological Sciences Research Council; Univerzita Karlova v Praze; Grantová Agentura České Republiky; Ministerstvo Školství, Mládeže a Tělovýchovy","keywords":"Biology; Translocase; Translocase of the inner membrane; Twin-arginine translocation pathway; Inner membrane; Mitochondrion; Transport protein; Cell biology; Mitochondrial membrane transport protein; Intermembrane space; Membrane transport protein; Biochemistry; Membrane protein; Bacterial outer membrane; Inner mitochondrial membrane; Gene; Escherichia coli; Membrane; Chromosomal translocation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001918545,0.0001952568,0.000326403,0.00009180875,0.00004954375,0.000002967155,0.0002712748,0.0003904368,0.00023989],"category_scores_gemma":[0.0001381012,0.0001403728,0.0001564621,0.0001800015,0.0008594748,0.000005096364,0.00003049344,0.000108972,0.00000686136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001049022,"about_ca_system_score_gemma":0.0001796596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002799115,"about_ca_topic_score_gemma":0.003800295,"domain_scores_codex":[0.9983753,0.0003592708,0.0005429711,0.0003844964,0.00007353287,0.0002644048],"domain_scores_gemma":[0.9992035,0.00004093716,0.0001966739,0.0003764091,0.0001406211,0.00004185885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002320794,0.00009436152,0.01775636,0.00003420201,0.00002317016,0.000001212231,0.0001094521,0.00001383007,0.9778591,0.001408161,0.0001700114,0.0002093251],"study_design_scores_gemma":[0.003394462,0.002914855,0.01028649,0.00004341773,0.00004864567,0.0000627043,0.0001584444,0.00006354121,0.9658524,0.001110913,0.01573615,0.0003279527],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828039,0.0003602516,0.01404287,0.00007293872,0.001676446,0.0005899117,0.0001427434,0.000009144363,0.0003018103],"genre_scores_gemma":[0.9945936,0.00002161602,0.003487838,0.00002924349,0.001360177,0.00006265694,0.0002100957,0.00001672311,0.0002180106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01556614,"threshold_uncertainty_score":0.5724237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01331709846507915,"score_gpt":0.2512493971546438,"score_spread":0.2379322986895647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}