{"id":"W2901656095","doi":"10.2217/pgs-2018-0099","title":"Pharmacogenetic Guidelines and Decision Support Tools for Depression Treatment: Application to Late-Life","year":2018,"lang":"en","type":"review","venue":"Pharmacogenomics","topic":"Treatment of Major Depression","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Toronto; Centre for Addiction and Mental Health","funders":"","keywords":"Pharmacogenetics; Polypharmacy; Depression (economics); Medicine; Pharmacogenomics; Clinical Practice; Psychiatry; Psychology; Intensive care medicine; Pharmacology; Family medicine; Genotype; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009394795,0.00124056,0.00214803,0.003990274,0.0003567495,0.002517512,0.001730023,0.002928046,0.007080929],"category_scores_gemma":[0.04035056,0.0004716372,0.002846516,0.003908949,0.0006275456,0.002074859,0.001286011,0.003828167,0.001522385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001810251,"about_ca_system_score_gemma":0.005724628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002643603,"about_ca_topic_score_gemma":0.004653279,"domain_scores_codex":[0.9932957,0.004259347,0.001073712,0.0002468165,0.001021929,0.0001024761],"domain_scores_gemma":[0.9704263,0.02537965,0.001823069,0.0003130889,0.00183529,0.0002226562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001034477,0.00007719632,0.0003705167,0.07352041,0.0009683307,0.0001788643,0.0002290377,0.001763501,0.0001661028,0.01697638,0.03459419,0.8710521],"study_design_scores_gemma":[0.0002999074,0.0001291437,0.001384205,0.2319008,0.002994392,0.0008759837,0.0002628537,0.001827945,0.0003025581,0.04049242,0.7194375,0.0000922063],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003777612,0.9776955,0.004953892,0.01168183,0.0007910867,0.000213313,0.0003935767,0.00006442296,0.003828542],"genre_scores_gemma":[0.007145206,0.970327,0.01587606,0.004500895,0.0007313428,0.0003193678,0.0004248148,0.00001956816,0.0006557772],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.009394795,"threshold_uncertainty_score":0.049685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2025682515600768,"score_gpt":0.4694821438982968,"score_spread":0.26691389233822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}