{"id":"W2901683899","doi":"10.1016/j.phymed.2018.11.029","title":"Sasanquasaponin ΙΙΙ from Schima crenata Korth induces autophagy through Akt/mTOR/p70S6K pathway and promotes apoptosis in human melanoma A375 cells","year":2018,"lang":"en","type":"article","venue":"Phytomedicine","topic":"Traditional Chinese Medicine Analysis","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Natural Science Foundation of China","keywords":"LAMP1; Autophagy; Apoptosis; PI3K/AKT/mTOR pathway; Annexin; Protein kinase B; Chemistry; Cancer cell; Cancer research; Reactive oxygen species; Biology; Molecular biology; Cell biology; Cancer; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005108778,0.0005902097,0.001377644,0.0006550588,0.000217867,0.00003557577,0.000305462,0.0002409182,0.001639715],"category_scores_gemma":[0.0003110907,0.0004499648,0.0001494245,0.001142968,0.0008589095,0.0003486427,0.0001330814,0.0007164215,0.00009431208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001496333,"about_ca_system_score_gemma":0.0001850797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00229373,"about_ca_topic_score_gemma":0.0003630889,"domain_scores_codex":[0.9961675,0.0001409572,0.0009701524,0.001022858,0.001043642,0.0006548839],"domain_scores_gemma":[0.9979247,0.0003255398,0.0002967859,0.0008059604,0.0002262028,0.0004207601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004605939,0.001263868,0.0670963,0.0004002172,0.0008185779,0.0004727217,0.006198541,0.000001276209,0.908446,0.0003410008,0.007793265,0.006707646],"study_design_scores_gemma":[0.007657204,0.002933941,0.327706,0.001564407,0.0006924552,0.00009125866,0.0008236979,0.0003171157,0.6504159,0.003543895,0.003580171,0.0006739314],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884128,0.001654036,0.0000903593,0.003747723,0.0004055628,0.0006215995,0.0001136006,0.0001872954,0.004767007],"genre_scores_gemma":[0.9915965,0.0001195314,0.001813184,0.001753444,0.003503073,0.0000694812,0.0006118395,0.00008534909,0.0004475609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2606097,"threshold_uncertainty_score":0.9997952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02588856314835979,"score_gpt":0.289702178985001,"score_spread":0.2638136158366412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}