{"id":"W2901703782","doi":"10.1126/scisignal.aap9921","title":"IFN-γ–inducible antiviral responses require ULK1-mediated activation of MLK3 and ERK5","year":2018,"lang":"en","type":"article","venue":"Science Signaling","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; U.S. Department of Veterans Affairs","keywords":"Protein kinase R; ASK1; Cyclin-dependent kinase 9; STAT1; MAP kinase kinase kinase; Cell biology; Cyclin-dependent kinase 2; Mitogen-activated protein kinase kinase; Biology; Kinase; ULK1; TANK-binding kinase 1; STAT protein; MAP2K7; Activator (genetics); Protein kinase A; Cancer research; Signal transduction; Biochemistry; Receptor; STAT3; AMPK","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001704985,0.0003054834,0.0002345445,0.0001891937,0.0003313557,0.0003786913,0.000131063,0.0001670604,0.001988177],"category_scores_gemma":[0.00009294834,0.0001166192,0.0004015287,0.0001246686,0.000202895,0.000297508,0.0003073592,0.0005225998,0.0006733775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006149365,"about_ca_system_score_gemma":0.0003429696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003459154,"about_ca_topic_score_gemma":0.0007708563,"domain_scores_codex":[0.9998498,0.00001960801,0.00001712818,0.00003115544,0.00003418787,0.00004799692],"domain_scores_gemma":[0.9999434,0.000005579389,0.00002025059,0.00000822918,0.000008312632,0.00001421606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002724598,0.00002809241,0.0005635035,0.00007829096,0.000009304576,0.00006110509,0.0000195638,0.00009656889,0.9958352,0.0004022166,0.00008722035,0.00254655],"study_design_scores_gemma":[0.00002066169,0.00008126695,0.01355652,0.00001186022,0.00001284744,0.0003549622,0.00004757518,0.0009952644,0.9794434,0.0002362626,0.005233266,0.000006079005],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838105,0.004082487,0.005610503,0.0002700201,0.00005790002,0.0000422827,0.0009108147,0.000147142,0.005068399],"genre_scores_gemma":[0.9934515,0.000821092,0.002231585,0.00006518494,0.000008428621,0.00002267323,0.0008970296,0.00001412832,0.002488411],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001988177,"threshold_uncertainty_score":0.006651103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03117026262358171,"score_gpt":0.3341691843138596,"score_spread":0.3029989216902779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}