{"id":"W2901716885","doi":"10.1186/s12885-018-5018-x","title":"Homoharringtonine interacts synergistically with bortezomib in NHL cells through MCL-1 and NOXA-dependent mechanisms","year":2018,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Leukemia and Lymphoma Society of Canada; Teva Pharmaceutical Industries; Leukemia and Lymphoma Society","keywords":"Bortezomib; Proteasome inhibitor; Homoharringtonine; Cancer research; Apoptosis; Chemistry; Proteasome; Gene knockdown; Pharmacology; Lymphoma; Medicine; Immunology; Multiple myeloma","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001067153,0.000160713,0.0001516523,0.0000247544,0.00005013487,0.00003192915,0.0001242565,0.0001021717,0.000193811],"category_scores_gemma":[0.00002514312,0.000133844,0.00002564057,0.00006032892,0.0001089552,0.000006409238,0.0001155372,0.00009190553,0.00001546924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002479904,"about_ca_system_score_gemma":0.0001209731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002631282,"about_ca_topic_score_gemma":0.002688319,"domain_scores_codex":[0.9990398,0.00003387227,0.0001555083,0.0003844932,0.0001161011,0.0002702697],"domain_scores_gemma":[0.9995458,0.00001135674,0.00005697143,0.000236116,0.00007063852,0.00007911011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004002188,0.00005837369,0.0011336,0.00005116953,0.00003169397,0.00001096975,0.0001917325,0.00002715186,0.9954135,0.0009854503,0.0004909923,0.001205084],"study_design_scores_gemma":[0.0008485523,0.0004780654,0.0009424228,0.00008511435,0.000015587,0.00001591552,0.00006004372,0.00007872258,0.9839476,0.0002737895,0.01302739,0.0002267574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814796,0.000616779,0.01281443,0.00009132615,0.0002405452,0.0002744995,0.00005367167,0.00001669921,0.004412395],"genre_scores_gemma":[0.9919313,0.000208235,0.005739077,0.0005414357,0.0003019877,0.00008316652,0.00001438099,0.00002796591,0.001152488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01253639,"threshold_uncertainty_score":0.5457999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01380358244140709,"score_gpt":0.2622935175433355,"score_spread":0.2484899351019284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}