{"id":"W2901720512","doi":"10.1002/glia.23548","title":"The guanine nucleotide exchange factor Vav3 modulates oligodendrocyte precursor differentiation and supports remyelination in white matter lesions","year":2018,"lang":"en","type":"article","venue":"Glia","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ruhr-Universität Bochum; Deutsche Forschungsgemeinschaft; Stem Cell Network","keywords":"Remyelination; RHOA; Oligodendrocyte; Biology; Guanine nucleotide exchange factor; Myelin; Cell biology; GTPase; Neuroscience; Signal transduction; Central nervous system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008841612,0.0001543086,0.0001219825,0.00009638542,0.000297746,0.0001155389,0.0001540527,0.00004917587,0.0002502782],"category_scores_gemma":[0.0001432234,0.0001147149,0.00003102029,0.0001731819,0.00008232868,0.0001808499,0.0001184972,0.0001000737,0.0001783996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001925359,"about_ca_system_score_gemma":0.000008839066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000740997,"about_ca_topic_score_gemma":0.00009876061,"domain_scores_codex":[0.9987006,0.0001470309,0.0002291942,0.0004063729,0.0002272487,0.0002895872],"domain_scores_gemma":[0.9994038,0.0001568514,0.000106228,0.0002281957,0.00003597931,0.00006889617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004772619,0.00005474412,0.007974797,0.00001687791,0.00000183257,0.00001506008,0.0005565038,0.000003629848,0.9888886,0.0004148404,0.000642241,0.001383172],"study_design_scores_gemma":[0.0002234205,0.0001003583,0.2532811,0.00001762463,0.00000713822,0.00001580541,0.00001127211,0.003087117,0.7421424,0.0002196492,0.0007753349,0.0001188554],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980536,0.00001797287,0.0003051296,0.0005238875,0.0005408841,0.0002716726,0.00002234028,0.0000482118,0.0002163601],"genre_scores_gemma":[0.9982067,0.0001298046,0.0000319582,0.0004244241,0.0001014999,0.00001907872,0.000002557618,0.00002695353,0.001057077],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2467462,"threshold_uncertainty_score":0.4677936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02291780508924236,"score_gpt":0.2508503958534435,"score_spread":0.2279325907642011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}