{"id":"W2901742569","doi":"10.1038/s41598-018-34978-4","title":"Mavoglurant in Fragile X Syndrome: Results of two open-label, extension trials in adults and adolescents","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"Mylan; Zynerba Pharmaceuticals; Teva Pharmaceutical Industries","keywords":"Fragile X syndrome; Placebo; Clinical endpoint; Medicine; Adverse effect; Metabotropic glutamate receptor 5; Antagonist; Metabotropic glutamate receptor; Randomized controlled trial; Pediatrics; Internal medicine; Psychiatry; Glutamate receptor; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002780937,0.0001239448,0.0002948063,0.0001416753,0.00006088704,0.00006040558,0.000164029,0.00007251672,0.000007149834],"category_scores_gemma":[0.0005735867,0.0001120535,0.00002555239,0.0002780811,0.0002205393,0.000007581716,0.0003308231,0.00005424365,0.000002553291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008628256,"about_ca_system_score_gemma":0.00009344233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001313779,"about_ca_topic_score_gemma":0.0005637215,"domain_scores_codex":[0.9977595,0.0001346971,0.0008834306,0.0007990925,0.0001985658,0.0002247427],"domain_scores_gemma":[0.9989859,0.000009875155,0.0003261884,0.0005106155,0.0001015479,0.00006580334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004648326,0.0003368985,0.01553216,0.0000420723,0.000006125083,0.0001571253,0.0001801528,0.00001267443,0.977369,0.000002047612,0.002928839,0.002968042],"study_design_scores_gemma":[0.01130484,0.000862241,0.4068975,0.001190737,0.0000134935,0.0003017391,0.0001836924,0.0002213114,0.5706441,0.001526613,0.006325282,0.0005283685],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976977,0.0002875083,0.000008127048,0.00004927329,0.001140974,0.0005198096,0.000008625255,0.000002527378,0.0002854758],"genre_scores_gemma":[0.9990566,0.00006305303,0.0004466348,0.00003810234,0.000007985378,0.00001212991,0.00006990979,0.00001123274,0.0002943865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4067249,"threshold_uncertainty_score":0.4569408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02857976507745276,"score_gpt":0.3058579932962618,"score_spread":0.277278228218809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}