{"id":"W2901766880","doi":"10.1101/472647","title":"Pioneer and nonpioneer factor cooperation drives lineage specific chromatin opening","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Compute Canada","keywords":"Chromatin; Enhancer; Heterochromatin; Scaffold/matrix attachment region; Transcription factor; Biology; Pioneer factor; Cell biology; ChIA-PET; Chromatin remodeling; Histone; Genetics; Computational biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002379416,0.0002401812,0.0002434895,0.0001998011,0.0002105178,0.0005840064,0.0002604018,0.000302385,0.003402882],"category_scores_gemma":[0.0002705916,0.0002268988,0.0002484325,0.00008680621,0.0003446808,0.0003226127,0.0007692812,0.0006687673,0.001020005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003927087,"about_ca_system_score_gemma":0.0002418645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006820604,"about_ca_topic_score_gemma":0.001254356,"domain_scores_codex":[0.9997292,0.00002376245,0.00001168796,0.0000955464,0.00007413841,0.00006562175],"domain_scores_gemma":[0.9996589,0.00008818702,0.00005193615,0.00008515184,0.00002638052,0.00008947792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003430271,0.000006448891,0.0003849185,0.00001033552,0.000002009693,0.00003778087,0.00001065381,0.00002688581,0.9985903,0.0002690445,0.00003380789,0.0005935587],"study_design_scores_gemma":[0.000009343017,0.00003517013,0.009304971,0.000003114025,0.000004726211,0.0001675945,0.00002999784,0.001952196,0.9858679,0.0002192803,0.002401155,0.000004581679],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864463,0.0006233922,0.008797249,0.00007577856,0.0000262832,0.00001344528,0.0002153565,0.0002018724,0.003600215],"genre_scores_gemma":[0.992211,0.0001227281,0.002557486,0.00003756004,0.000007842579,0.000008264446,0.0002802678,0.00007022187,0.004704642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003402882,"threshold_uncertainty_score":0.01138377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009311331963742408,"score_gpt":0.2085886675086239,"score_spread":0.1992773355448815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}