{"id":"W2901794353","doi":"10.1038/s41598-018-34855-0","title":"Safranal induces DNA double-strand breakage and ER-stress-mediated cell death in hepatocellular carcinoma cells","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Saffron Plant Research Studies","field":"Medicine","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"United Arab Emirates University; York University; New York University Abu Dhabi","keywords":"Safranal; Apoptosis; Cell cycle; DNA damage; DNA repair; Cancer research; Biology; Cell cycle checkpoint; Cell biology; Chemistry; Molecular biology; DNA; Genetics; Pharmacology; Crocin","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001363904,0.0003045378,0.0002872463,0.0004225385,0.0001513483,0.0001916388,0.0001051534,0.0001433684,0.0007836277],"category_scores_gemma":[0.0001400739,0.00008867987,0.0004959076,0.0003392605,0.0001162651,0.0002210492,0.0001342161,0.0002100745,0.0001465316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002457478,"about_ca_system_score_gemma":0.0001628017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008556878,"about_ca_topic_score_gemma":0.001082045,"domain_scores_codex":[0.9999226,0.00001315536,0.000005409955,0.00001761958,0.00002486856,0.00001625648],"domain_scores_gemma":[0.9998927,0.00002064991,0.00004485113,0.00001064883,0.00002148771,0.000009720609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003892533,0.0000592967,0.004843274,0.0002254274,0.00005736851,0.0001478285,0.00002895071,0.002670215,0.9822991,0.00012348,0.00007988662,0.00907587],"study_design_scores_gemma":[0.00002531206,0.0009173608,0.04934875,0.00001322241,0.0001410669,0.0002543335,0.00008887491,0.02454613,0.9215884,0.0003652931,0.00269682,0.00001450998],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937312,0.001003404,0.003872646,0.00004527178,0.00001089608,0.00002329436,0.0005655563,0.000129624,0.0006181197],"genre_scores_gemma":[0.9957985,0.0006592143,0.002107918,0.0000232374,0.000004782385,0.00001575669,0.0008388218,0.000008235041,0.0005435444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008556878,"threshold_uncertainty_score":0.002621472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03148278550200229,"score_gpt":0.275073363662772,"score_spread":0.2435905781607697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}