{"id":"W2901827169","doi":"10.1002/tox.22681","title":"Para‐tertiary butyl catechol (PTBC), an industrial antioxidant induces human platelet apoptosis","year":2018,"lang":"en","type":"article","venue":"Environmental Toxicology","topic":"Contact Dermatitis and Allergies","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Manitoba","funders":"","keywords":"Reactive oxygen species; Chemistry; Apoptosis; Platelet; Platelet activation; Mitochondrial permeability transition pore; Antioxidant; Phosphatidylserine; Glutathione; Pharmacology; Biochemistry; Cell biology; Immunology; Programmed cell death; Biology; Membrane; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001269177,0.0002428388,0.0003711044,0.0001198289,0.0002444469,0.00002762015,0.000168238,0.0003323513,0.003535308],"category_scores_gemma":[0.0000139949,0.0002222666,0.00008603671,0.00006029174,0.000416607,0.0002051749,0.0001354056,0.0003512948,0.0003657645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001415322,"about_ca_system_score_gemma":0.0000300949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006085978,"about_ca_topic_score_gemma":0.00005395838,"domain_scores_codex":[0.998485,0.00009735538,0.0003756158,0.000411424,0.0002161251,0.0004144552],"domain_scores_gemma":[0.9992706,0.00002785148,0.0001190474,0.0003659689,0.000005249035,0.0002113164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008991267,0.0006081216,0.02576713,0.000005110705,0.00008737399,0.00007678774,0.0003945241,3.470235e-7,0.9600199,0.00005426408,0.001829025,0.01106751],"study_design_scores_gemma":[0.002872472,0.002425017,0.3157491,0.00003062918,0.00005179396,0.0002141468,0.0004304915,0.00001574072,0.6511521,0.00006666824,0.02668197,0.0003098559],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966765,0.00005945702,0.000009073955,0.0008490562,0.0005190548,0.0004172239,0.00002903227,0.00008278953,0.001357831],"genre_scores_gemma":[0.9962523,0.00005818859,0.0001318443,0.001538251,0.0009175575,0.00004522469,0.0001055692,0.00003438785,0.0009166677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3088678,"threshold_uncertainty_score":0.9973756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03797316754298063,"score_gpt":0.2850244302345543,"score_spread":0.2470512626915737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}