{"id":"W2901892827","doi":"10.1016/j.bbrc.2018.11.075","title":"Nobiletin reduces LPL-mediated lipid accumulation and pro-inflammatory cytokine secretion through upregulation of miR-590 expression","year":2018,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Bioactive Compounds in Plants","field":"Agricultural and Biological Sciences","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"University of South China","keywords":"Nobiletin; Western blot; Oil Red O; Cytokine; Secretion; Downregulation and upregulation; Chemistry; Pharmacology; Endocrinology; Biology; Biochemistry; Immunology; Adipose tissue; Flavonoid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001958408,0.0004234693,0.0004677066,0.0002318181,0.0002073619,0.0004015059,0.0002104337,0.0003565907,0.001448685],"category_scores_gemma":[0.0002664469,0.0002061322,0.0003209001,0.0001070973,0.0004786986,0.0003311836,0.0002103948,0.001244291,0.0004915239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003345365,"about_ca_system_score_gemma":0.0003920061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006764621,"about_ca_topic_score_gemma":0.0006793251,"domain_scores_codex":[0.999778,0.00004178041,0.00002500947,0.00004999716,0.00004804861,0.0000571865],"domain_scores_gemma":[0.999868,0.00002387634,0.00003077034,0.00001385945,0.0000170511,0.00004646284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001118096,0.0001003096,0.00009964361,0.00006030822,0.000008721538,0.00004221953,0.0000158767,0.00002881418,0.9968032,0.00009402451,0.0001106512,0.001518284],"study_design_scores_gemma":[0.0001795875,0.0008127063,0.003159123,0.00001109994,0.00006517483,0.0001828168,0.00006144051,0.0009086125,0.9887835,0.0002052894,0.00561648,0.00001419226],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857489,0.003738292,0.00433892,0.0006074374,0.0003549073,0.00006492836,0.0004653886,0.0003788222,0.00430238],"genre_scores_gemma":[0.9905495,0.001278951,0.002533839,0.0002332101,0.00004330816,0.00008478186,0.0004528114,0.00004903963,0.004774521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001448685,"threshold_uncertainty_score":0.004846334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1644618872914735,"score_gpt":0.3838110171441137,"score_spread":0.2193491298526402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}