{"id":"W2901903789","doi":"10.1101/470336","title":"A revised biosynthetic pathway for the cofactor F <sub>420</sub> in bacteria","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Health Research Council of New Zealand; National Health and Medical Research Council; Australian Research Council; Medical Research Council","keywords":"Bacteria; Cofactor; DNA ligase; Biochemistry; Archaea; Heterologous expression; Biosynthesis; Escherichia coli; Enzyme; Biology; Chemistry; Stereochemistry; Recombinant DNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001325633,0.0006176928,0.0006521556,0.0002148305,0.0002704855,0.0004203632,0.0008664502,0.0006121359,0.0001920751],"category_scores_gemma":[0.0005547253,0.0004812829,0.0002150142,0.0003711602,0.0002665029,0.0001802935,0.0003981488,0.0004903774,0.0001972598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002598895,"about_ca_system_score_gemma":0.0006094676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004292854,"about_ca_topic_score_gemma":0.00001669381,"domain_scores_codex":[0.9968244,0.0002139887,0.000709308,0.001167297,0.000360826,0.0007242048],"domain_scores_gemma":[0.9969493,0.0002629993,0.000543353,0.001637638,0.0004324731,0.0001742679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009894818,0.00004414786,0.0003544409,0.0003120163,0.00003037813,0.000006360578,0.0000169312,0.00000923945,0.9981965,0.0001920204,0.0007337201,0.000005308806],"study_design_scores_gemma":[0.0004865564,0.00008070406,0.02369741,0.0004169386,0.00008454568,2.171657e-8,0.000002220057,0.0001589646,0.9664875,0.00001221375,0.007982589,0.0005903778],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889467,0.0005661616,0.002162855,0.0002544576,0.005425323,0.001708603,0.0006384508,0.000290921,0.000006548254],"genre_scores_gemma":[0.9954903,0.0001300594,0.002026474,0.0002728352,0.001378381,0.0005646561,7.975718e-7,0.0001333359,0.000003146917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03170903,"threshold_uncertainty_score":0.9997639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01479727216349113,"score_gpt":0.212525814707344,"score_spread":0.1977285425438528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}