{"id":"W2901933822","doi":"10.1038/s41598-018-35789-3","title":"Systematic Analysis and Biomarker Study for Alzheimer’s Disease","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Horizon 2020 Framework Programme; National Institutes of Health; IXICO; Centre hospitalier régional universitaire de Lille; H. Lundbeck A/S; Northern California Institute for Research and Education; Hjartavernd; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease; Eisai; Genentech; Erasmus Medisch Centrum; Servier; Engineering and Physical Sciences Research Council; Institut National de la Santé et de la Recherche Médicale; Bundesministerium für Bildung und Forschung; F. Hoffmann-La Roche; Agence Nationale de la Recherche; Wellcome Trust; University of Southern California; Pfizer; Biogen; BioClinica; National Heart, Lung, and Blood Institute; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Université de Lille; Medical Research Council; Meso Scale Diagnostics; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Disease; Biomarker; Pathogenesis; Alzheimer's disease; Case-control study; Gene; Biology; Bioinformatics; Medicine; Internal medicine; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001996647,0.0002778102,0.0008855142,0.00261623,0.0003817968,0.0004547002,0.0002153188,0.0002498485,0.0003243258],"category_scores_gemma":[0.002790039,0.0001077754,0.0007810743,0.003363564,0.0002661044,0.0002061056,0.0004786667,0.0002391155,0.00008555005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002788912,"about_ca_system_score_gemma":0.0008898175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001510404,"about_ca_topic_score_gemma":0.00312241,"domain_scores_codex":[0.9987273,0.0004427066,0.0001992385,0.0003088972,0.0002549468,0.00006707976],"domain_scores_gemma":[0.9978648,0.000586604,0.0006781381,0.0002468608,0.0004829273,0.0001406819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008985618,0.0000745102,0.9419584,0.0007316705,0.001761461,0.0002904913,0.0001269059,0.0002533427,0.01646244,0.0001961609,0.001068399,0.03617763],"study_design_scores_gemma":[0.00004089476,0.0003943969,0.988508,0.00009930698,0.001527481,0.0006694102,0.0001730879,0.0007792212,0.003722176,0.0005161472,0.003552142,0.00001766761],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.972277,0.01907571,0.003080982,0.0003029429,0.00007894279,0.0001026411,0.004423693,0.00003954757,0.0006184629],"genre_scores_gemma":[0.9887869,0.002904894,0.003850385,0.0002023759,0.00004628802,0.0000673975,0.003917007,0.000009326209,0.0002153986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00261623,"threshold_uncertainty_score":0.01055944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05109655151960117,"score_gpt":0.3648852870090509,"score_spread":0.3137887354894497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}