{"id":"W2901969195","doi":"10.1016/j.jbiotec.2018.11.017","title":"Engineering diverse eubacteria promoters for robust Gene expression in Streptomyces lividans","year":2018,"lang":"en","type":"article","venue":"Journal of Biotechnology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Fundamental Research Funds for the Central Universities; National Natural Science Foundation of China; Petroleum Technology Alliance Canada","keywords":"Promoter; Streptomyces; Streptomyces albus; Heterologous; Biology; Gene; Ribosomal binding site; Gene expression; Computational biology; Genetics; RNA; Ribosome; Bacteria","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004263586,0.0004450979,0.0003657523,0.0003403072,0.000173714,0.0007015899,0.0003064072,0.0002348835,0.0002743921],"category_scores_gemma":[0.0003478146,0.0002165154,0.0002757459,0.000421338,0.0002973974,0.0002995155,0.0006606527,0.0006985322,0.0002253601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000432761,"about_ca_system_score_gemma":0.0002910946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004358125,"about_ca_topic_score_gemma":0.0008912265,"domain_scores_codex":[0.9996285,0.0000603077,0.00005072774,0.00006850423,0.0001328223,0.00005894417],"domain_scores_gemma":[0.9998028,0.00004688805,0.00005937253,0.00002603834,0.00002262684,0.00004229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001067455,0.00003168943,0.0002265773,0.00002710307,0.000005040532,0.0000346033,0.00002002384,0.0002647704,0.9959125,0.000164603,0.00001879978,0.003187628],"study_design_scores_gemma":[0.00002330169,0.0001655429,0.000768684,0.000007265961,0.00001895259,0.00009448854,0.00003686632,0.001809138,0.9953794,0.000110203,0.00157745,0.000008603579],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9809771,0.001008016,0.01580708,0.0001187638,0.00004141432,0.00004239554,0.0002093016,0.0002612742,0.001534661],"genre_scores_gemma":[0.9892953,0.0003559861,0.008911306,0.00003106561,0.000005997183,0.00001814728,0.0003047447,0.00008409718,0.0009933348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007015899,"threshold_uncertainty_score":0.003139913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01554006558851138,"score_gpt":0.2383206782956156,"score_spread":0.2227806127071043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}