{"id":"W2901969195","doi":"10.1016/j.jbiotec.2018.11.017","title":"Engineering diverse eubacteria promoters for robust Gene expression in Streptomyces lividans","year":2018,"lang":"en","type":"article","venue":"Journal of Biotechnology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Fundamental Research Funds for the Central Universities; National Natural Science Foundation of China; Petroleum Technology Alliance Canada","keywords":"Promoter; Streptomyces; Streptomyces albus; Heterologous; Biology; Gene; Ribosomal binding site; Gene expression; Computational biology; Genetics; RNA; Ribosome; Bacteria","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002181253,0.00009465734,0.0002612548,0.0003361062,0.0000267612,0.000008125994,0.0001248038,0.0002548274,0.00006798021],"category_scores_gemma":[0.0003016144,0.00006527656,0.00007306568,0.000158259,0.00007386768,0.00007121723,0.00004532073,0.0002310285,0.000003307193],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005517537,"about_ca_system_score_gemma":0.00003430205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003308443,"about_ca_topic_score_gemma":0.000005690483,"domain_scores_codex":[0.9993182,0.000009543863,0.0002877284,0.0001359335,0.0000692918,0.0001792472],"domain_scores_gemma":[0.9995335,0.00002357597,0.0001740967,0.0001357501,0.00008924925,0.00004377889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002411573,0.00006454164,0.0002959365,0.00004190798,0.00002589635,0.00002990234,0.00007397604,0.000003243911,0.9895473,0.00000552037,0.0007882395,0.008882354],"study_design_scores_gemma":[0.000714346,0.000780012,0.001748093,0.0002526542,0.00003273734,0.0002600758,0.00007427407,0.00008696906,0.9898806,0.000009441146,0.00608993,0.00007087274],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936327,0.0001442915,0.0009938809,0.004656282,0.0003597774,0.000177941,0.00000571289,0.00002334864,0.000006019682],"genre_scores_gemma":[0.9552928,0.000115222,0.04404676,0.00005799046,0.0004252967,3.687458e-7,0.000001291486,0.00001074808,0.00004956842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04305288,"threshold_uncertainty_score":0.2661901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01554006558851138,"score_gpt":0.2383206782956156,"score_spread":0.2227806127071043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}