{"id":"W2901983499","doi":"10.18433/jpps30022","title":"Non-alcoholic Steatohepatitis (NASH) Drug Discovery – Building a Consensus on ADME Screening Tools and Clinical Pharmacology Strategies to Aid Candidate Development","year":2018,"lang":"en","type":"review","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"ADME; Steatohepatitis; Pharmacology; Drug development; Medicine; Drug; Drug metabolism; Bioinformatics; Fatty liver; Biology; Disease; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01137731,0.001013347,0.002842585,0.00303919,0.0005509307,0.002939212,0.001925239,0.00216886,0.002580511],"category_scores_gemma":[0.004381996,0.0005692621,0.001263324,0.001421272,0.001945759,0.002826298,0.002560839,0.004533187,0.001870981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001237075,"about_ca_system_score_gemma":0.004030923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000606132,"about_ca_topic_score_gemma":0.001044234,"domain_scores_codex":[0.9957523,0.001381592,0.0004724322,0.0005629435,0.001625468,0.0002051703],"domain_scores_gemma":[0.995882,0.001431421,0.0005124097,0.0003212671,0.001583233,0.0002696305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003241047,0.0004299307,0.001426881,0.01244946,0.0002660815,0.0006604588,0.0002860729,0.004449182,0.0730112,0.07445008,0.0211474,0.8110991],"study_design_scores_gemma":[0.0001249709,0.002299088,0.002241596,0.004802072,0.0003793837,0.002731535,0.0003621629,0.006396824,0.07077657,0.03586915,0.8737988,0.0002177389],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01480784,0.6939996,0.2218606,0.02962237,0.001926544,0.001075769,0.0009770259,0.0007770809,0.03495319],"genre_scores_gemma":[0.1067384,0.6340844,0.2269965,0.0133088,0.001515677,0.0009190267,0.001776263,0.0002127698,0.01444833],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01137731,"threshold_uncertainty_score":0.06016964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1991401522912085,"score_gpt":0.5138510693098337,"score_spread":0.3147109170186252,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}