{"id":"W2902031310","doi":"10.1146/annurev-cancerbio-030518-055533","title":"HSP90: Enabler of Cancer Adaptation","year":2018,"lang":"en","type":"article","venue":"Annual Review of Cancer Biology","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Damon Runyon Cancer Research Foundation","keywords":"Hsp90; Heat shock protein; Cancer; Function (biology); Biology; Hsp90 inhibitor; Adaptability; Computational biology; Bioinformatics; Cancer research; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003180314,0.0003261543,0.0004731538,0.0003377475,0.0002248546,0.00102681,0.0003798809,0.0006449607,0.0009726602],"category_scores_gemma":[0.0002127431,0.0001713025,0.0002447956,0.0003447804,0.0008495236,0.000964861,0.0007504863,0.001443939,0.0008297375],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00061349,"about_ca_system_score_gemma":0.0003832416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002860195,"about_ca_topic_score_gemma":0.000326451,"domain_scores_codex":[0.9998242,0.00003503352,0.000009125862,0.00003930819,0.00005261121,0.00003972814],"domain_scores_gemma":[0.9999235,0.00001499957,0.00001907479,0.000008046307,0.00001673574,0.00001767011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002798056,0.00008117073,0.00180385,0.004618512,0.0001463756,0.0013418,0.0006223151,0.001877562,0.3100365,0.1762258,0.03079245,0.4721738],"study_design_scores_gemma":[0.00002602785,0.00034575,0.004543046,0.0004068975,0.00006557751,0.003034316,0.0002841611,0.0004109072,0.07046857,0.03324626,0.8871319,0.00003671139],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03321032,0.9297053,0.008168432,0.007516846,0.001304915,0.00002764904,0.0001349143,0.0002837411,0.01964794],"genre_scores_gemma":[0.2523541,0.7323251,0.001879277,0.002018772,0.001027607,0.0000266245,0.0001342764,0.00003251151,0.0102017],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00102681,"threshold_uncertainty_score":0.004451215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02550013208071948,"score_gpt":0.3977981901910891,"score_spread":0.3722980581103696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}