{"id":"W2902053966","doi":"10.3390/cells7120247","title":"Paradoxical Role of Matrix Metalloproteinases in Liver Injury and Regeneration after Sterile Acute Hepatic Failure","year":2018,"lang":"en","type":"article","venue":"Cells","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Calgary","funders":"Fundação de Amparo à Pesquisa do Estado de Minas Gerais; Fundação de Desenvolvimento da Pesquisa; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Liver injury; Matrix metalloproteinase; Medicine; Acetaminophen; Inflammation; Matrix metalloproteinase inhibitor; Pharmacology; Necrosis; Intravital microscopy; Hepatocyte; Immunology; Pathology; Biology; Microcirculation; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000433504,0.0002485576,0.0003137612,0.0003261005,0.0001000706,0.0003279161,0.0001340899,0.0002422349,0.0007413508],"category_scores_gemma":[0.0004424523,0.00007599073,0.0001691727,0.0001556111,0.0003741602,0.0002793063,0.0002407461,0.0003688844,0.0001318814],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001843748,"about_ca_system_score_gemma":0.0001508437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001199099,"about_ca_topic_score_gemma":0.0001377514,"domain_scores_codex":[0.9998237,0.00005672092,0.00002016953,0.00002402212,0.00004702849,0.0000282976],"domain_scores_gemma":[0.9996526,0.00006497521,0.0001482347,0.00003217169,0.00003684101,0.00006517542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004282576,0.0001699822,0.01640989,0.0004998246,0.000047714,0.002553823,0.0002490632,0.0002472488,0.9474939,0.0007486709,0.0001582277,0.02713914],"study_design_scores_gemma":[0.0001802825,0.006227309,0.3379793,0.0001064403,0.0002092226,0.009203489,0.0006530056,0.003772608,0.633088,0.001911994,0.006630946,0.00003733612],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983914,0.01194131,0.002992142,0.0001692551,0.00003135709,0.00003041322,0.00005579535,0.00005034502,0.0008153809],"genre_scores_gemma":[0.9974903,0.001439781,0.0006563938,0.00003227406,0.00002253355,0.00001198863,0.00003408872,0.000003311202,0.0003092481],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007413508,"threshold_uncertainty_score":0.00248009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03494421892849427,"score_gpt":0.364232090133648,"score_spread":0.3292878712051538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}