{"id":"W2902053966","doi":"10.3390/cells7120247","title":"Paradoxical Role of Matrix Metalloproteinases in Liver Injury and Regeneration after Sterile Acute Hepatic Failure","year":2018,"lang":"en","type":"article","venue":"Cells","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Calgary","funders":"Fundação de Amparo à Pesquisa do Estado de Minas Gerais; Fundação de Desenvolvimento da Pesquisa; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Liver injury; Matrix metalloproteinase; Medicine; Acetaminophen; Inflammation; Matrix metalloproteinase inhibitor; Pharmacology; Necrosis; Intravital microscopy; Hepatocyte; Immunology; Pathology; Biology; Microcirculation; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003503986,0.0001466903,0.0002217954,0.0001164411,0.0000864495,0.00001541939,0.00008500577,0.0003195809,0.0007438752],"category_scores_gemma":[0.00001489298,0.0001412857,0.00004768423,0.0001616515,0.0001908245,0.0001610247,0.00006129654,0.0003342577,0.0001126045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003087936,"about_ca_system_score_gemma":0.00003099277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006452411,"about_ca_topic_score_gemma":0.0001871234,"domain_scores_codex":[0.9988385,0.0003327765,0.0002755596,0.0002365547,0.00009417383,0.0002223751],"domain_scores_gemma":[0.9995654,0.00006146784,0.00009619358,0.0001349168,0.00005335956,0.00008871643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006020571,0.000159402,0.002215852,0.00006728131,0.00005800433,0.00001859623,0.0009555798,0.00001008194,0.9824215,0.0001530425,0.0001951088,0.01314349],"study_design_scores_gemma":[0.0004612943,0.0002873018,0.001816512,0.00002204424,0.00008182413,0.00001008832,0.00005248149,0.003097669,0.9763966,0.0006624957,0.01695538,0.0001563218],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980261,0.0004618957,0.00009127191,0.0001211703,0.0003096735,0.0005200919,0.00004946085,0.00002593755,0.0003944256],"genre_scores_gemma":[0.9982419,0.0002118499,0.0006009648,0.0002430599,0.000204057,0.0001034278,0.000008108818,0.00001330861,0.0003733266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01676027,"threshold_uncertainty_score":0.8144912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03494421892849427,"score_gpt":0.364232090133648,"score_spread":0.3292878712051538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}