{"id":"W2902091069","doi":"10.1111/exd.13850","title":"Membrane‐enriched solute carrier family 2 member 1 (<scp>SLC</scp>2A1/<scp>GLUT</scp>1) in psoriatic keratinocytes confers sensitivity to 2‐deoxy‐D‐glucose (2‐<scp>DG</scp>) treatment","year":2018,"lang":"en","type":"article","venue":"Experimental Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health","funders":"Health and Family Planning Commission of Hunan Province; National Natural Science Foundation of China","keywords":"Psoriasis; Glycolysis; Glucose uptake; Glucose transporter; Chemistry; Carbohydrate metabolism; Cancer research; Imiquimod; Keratinocyte; Pharmacology; In vivo; Biochemistry; Cell biology; Biology; Metabolism; Endocrinology; In vitro; Immunology; Insulin; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.0003795211,0.001429275,0.002043833,0.0006769784,0.00077166,0.0001137956,0.0005316125,0.001271404,0.0001642731],"category_scores_gemma":[0.0005040704,0.0013463,0.0005169807,0.0006675547,0.0008458953,0.0004184656,0.0004241988,0.000471873,0.003765517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006879455,"about_ca_system_score_gemma":0.0003934031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001274896,"about_ca_topic_score_gemma":0.0008027052,"domain_scores_codex":[0.9926453,0.001787168,0.001274466,0.001756234,0.0002348193,0.002302031],"domain_scores_gemma":[0.9957013,0.002132615,0.0004569402,0.00112572,0.000204283,0.0003791054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001209339,0.001677678,0.009492288,0.00004086239,0.001612552,0.0008930202,0.01802453,0.00001423857,0.9423736,0.0008994781,0.02318052,0.001670336],"study_design_scores_gemma":[0.007830112,0.0009974501,0.01230457,0.00004793453,0.0003262262,0.001220576,0.009328218,0.00007416932,0.8916469,0.00004254981,0.07592711,0.0002542149],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9707142,0.009355342,0.00007534309,0.0001417384,0.003663523,0.001761214,0.0003606638,0.0003868612,0.01354115],"genre_scores_gemma":[0.9898247,0.0003865912,0.000502969,0.001363224,0.0003180801,0.000782376,0.0007539677,0.0001611664,0.005906945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05274659,"threshold_uncertainty_score":0.9998457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02311769118345947,"score_gpt":0.2686647935618591,"score_spread":0.2455471023783996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}