{"id":"W2902091069","doi":"10.1111/exd.13850","title":"Membrane‐enriched solute carrier family 2 member 1 (<scp>SLC</scp>2A1/<scp>GLUT</scp>1) in psoriatic keratinocytes confers sensitivity to 2‐deoxy‐D‐glucose (2‐<scp>DG</scp>) treatment","year":2018,"lang":"en","type":"article","venue":"Experimental Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health","funders":"Health and Family Planning Commission of Hunan Province; National Natural Science Foundation of China","keywords":"Psoriasis; Glycolysis; Glucose uptake; Glucose transporter; Chemistry; Carbohydrate metabolism; Cancer research; Imiquimod; Keratinocyte; Pharmacology; In vivo; Biochemistry; Cell biology; Biology; Metabolism; Endocrinology; In vitro; Immunology; Insulin; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007735849,0.0001393417,0.0002262934,0.0001882431,0.0001521693,0.0002367016,0.00006026679,0.0002123273,0.001261028],"category_scores_gemma":[0.00007351614,0.0001022846,0.000165326,0.0001439678,0.0001548667,0.0001529498,0.00009130469,0.0004249415,0.0002309143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001580937,"about_ca_system_score_gemma":0.000129171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005812296,"about_ca_topic_score_gemma":0.0005727477,"domain_scores_codex":[0.9998688,0.00002362636,0.00001012515,0.0000245818,0.00003418972,0.00003872867],"domain_scores_gemma":[0.9999458,0.000007328058,0.00001051692,0.000009150058,0.000006224469,0.00002111144],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008171229,0.00003137472,0.0002106541,0.00001159345,0.000001975913,0.00005762901,0.000007498409,0.00001328556,0.9989474,0.00002164006,0.00002626085,0.0005889533],"study_design_scores_gemma":[0.00002027059,0.0005668249,0.01868512,0.00000474147,0.00002166713,0.001236364,0.00009462135,0.001054172,0.9763708,0.00006163627,0.001877387,0.000006491015],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982265,0.000508591,0.0005758923,0.00005039066,0.00001939248,0.000008161956,0.00009805071,0.00003311471,0.000480027],"genre_scores_gemma":[0.9978907,0.0003415636,0.0005377278,0.0000320837,0.00000661089,0.000008866956,0.0001372094,0.000007029608,0.001038152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001261028,"threshold_uncertainty_score":0.004218578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02311769118345947,"score_gpt":0.2686647935618591,"score_spread":0.2455471023783996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}