{"id":"W2902093007","doi":"10.1038/s41388-018-0579-3","title":"ERRα promotes breast cancer cell dissemination to bone by increasing RANK expression in primary breast tumors","year":2018,"lang":"en","type":"article","venue":"Oncogene","topic":"Bone health and treatments","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"LabEx DEvweCAN; National Cancer Institute; Institut National Du Cancer; European Federation of Pharmaceutical Industries and Associations; Centre National de la Recherche Scientifique; Agence Nationale de la Recherche; Institut National de la Santé et de la Recherche Médicale","keywords":"Breast cancer; Cancer research; Biology; Primary tumor; Cancer; RANKL; Bone metastasis; Metastasis; In vivo; Metastatic breast cancer; Cancer cell; Oncology; Internal medicine; Medicine; Receptor; Activator (genetics)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002470952,0.0004294549,0.0005615432,0.0006433688,0.0002966665,0.000718636,0.000283194,0.0004361714,0.007497668],"category_scores_gemma":[0.0003148144,0.0003027759,0.0005439397,0.0003761205,0.0003316623,0.000273232,0.0002365261,0.001260979,0.002752813],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004445738,"about_ca_system_score_gemma":0.0004290731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001202037,"about_ca_topic_score_gemma":0.002784753,"domain_scores_codex":[0.9996094,0.0000490735,0.00001977827,0.0000396795,0.0001252266,0.000156845],"domain_scores_gemma":[0.9997701,0.0000324141,0.00005519469,0.00003236344,0.00005435406,0.00005554144],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001049661,0.0002683956,0.002215821,0.0002850212,0.00005301479,0.0003310397,0.00006267674,0.0001834328,0.9817575,0.0003494351,0.002188061,0.01125596],"study_design_scores_gemma":[0.0001720131,0.001230218,0.03311186,0.00004205337,0.0001766691,0.002107735,0.0005024726,0.0008384946,0.9342254,0.0003345436,0.02723668,0.0000218826],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9713098,0.01275197,0.003868132,0.001327763,0.0003092549,0.00004284142,0.002567326,0.000600942,0.007221944],"genre_scores_gemma":[0.9743095,0.004526185,0.00158434,0.0002059639,0.00007731944,0.00003073455,0.001775255,0.00007886526,0.0174119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007497668,"threshold_uncertainty_score":0.02508217,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007972744591346888,"score_gpt":0.2940832316658776,"score_spread":0.2861104870745307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}