{"id":"W2902097866","doi":"10.1007/s12035-018-1437-6","title":"In Schizophrenia, Deficits in Natural IgM Isotype Antibodies Including those Directed to Malondialdehyde and Azelaic Acid Strongly Predict Negative Symptoms, Neurocognitive Impairments, and the Deficit Syndrome","year":2018,"lang":"en","type":"article","venue":"Molecular Neurobiology","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":38,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Chulalongkorn University; Asahi Glass Foundation","keywords":"Immunology; Schizophrenia (object-oriented programming); Antibody; Autoantibody; Internal medicine; Malondialdehyde; Cognitive deficit; Medicine; Oxidative stress; Psychiatry; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00055993,0.001182893,0.0003188991,0.001375215,0.0005491499,0.0004508235,0.0003548503,0.0004598066,0.002979119],"category_scores_gemma":[0.001592119,0.0001970803,0.0002800769,0.0004716759,0.0007063598,0.0003569518,0.0005651391,0.0004689099,0.0003515758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004455851,"about_ca_system_score_gemma":0.0004957627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005305225,"about_ca_topic_score_gemma":0.006249501,"domain_scores_codex":[0.9997874,0.000040353,0.00003229672,0.00003469225,0.00006582684,0.00003946849],"domain_scores_gemma":[0.9988011,0.0001956091,0.0005979555,0.00006591234,0.0001277135,0.0002116364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001265851,0.0002552084,0.9274898,0.0001461014,0.0001768961,0.002873295,0.0002231664,0.0003353861,0.05346974,0.0002770396,0.0004145548,0.01307303],"study_design_scores_gemma":[0.00001795431,0.0006655748,0.9854644,0.00002651246,0.0001081622,0.005883926,0.0002669843,0.0003261071,0.006182881,0.0006638461,0.0003801077,0.00001349433],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958263,0.0002511139,0.0004063685,0.0001014912,0.00001420958,0.00002442819,0.0002678871,0.00003069396,0.003077353],"genre_scores_gemma":[0.9989863,0.0001560008,0.0003143169,0.00003571393,0.000005904519,0.00000727652,0.0001758812,0.000004608251,0.0003139418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005305225,"threshold_uncertainty_score":0.01054871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01062472894684586,"score_gpt":0.2552898347417257,"score_spread":0.2446651057948798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}