{"id":"W2902110767","doi":"10.1523/jneurosci.1148-18.2018","title":"Conditional Knock-out of mGluR5 from Astrocytes during Epilepsy Development Impairs High-Frequency Glutamate Uptake","year":2018,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nexen (Canada)","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Metabotropic glutamate receptor 5; Epileptogenesis; Astrocyte; Neuroscience; Metabotropic glutamate receptor; Glutamate receptor; Epilepsy; Biology; Conditional gene knockout; Metabotropic glutamate receptor 1; Cell biology; Receptor; Phenotype; Central nervous system; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001889275,0.0005109016,0.0003273508,0.0003847542,0.000221175,0.000356998,0.0003812018,0.0004277782,0.00150647],"category_scores_gemma":[0.0001556176,0.0002957977,0.0004368613,0.0001874461,0.0003825927,0.0002997255,0.0003368415,0.0007507181,0.0006143663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003308778,"about_ca_system_score_gemma":0.0004219235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001811176,"about_ca_topic_score_gemma":0.003371265,"domain_scores_codex":[0.9996152,0.00003956351,0.00007295841,0.00006438894,0.0001139746,0.00009398532],"domain_scores_gemma":[0.9997243,0.00002750385,0.0001058609,0.00002636271,0.00002092863,0.00009501138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008657452,0.00002681035,0.0001078501,0.00002412243,0.000005521149,0.00009155462,0.00002202785,0.0000484862,0.9989035,0.0001323093,0.00002764706,0.000523616],"study_design_scores_gemma":[0.00001967229,0.0002833336,0.003383317,0.000007435252,0.00002497358,0.0003100696,0.00005524907,0.0007052259,0.9935763,0.00005566525,0.001572483,0.000006336214],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898879,0.000949745,0.006041076,0.0001913961,0.000071541,0.00005796137,0.0008726282,0.0002233556,0.001704406],"genre_scores_gemma":[0.990302,0.0008097962,0.00329407,0.00009164631,0.00001278523,0.00008599593,0.000669358,0.00006941387,0.004665011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001811176,"threshold_uncertainty_score":0.005039692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05100991764455286,"score_gpt":0.3280276542033522,"score_spread":0.2770177365587993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}