{"id":"W2902126662","doi":"10.1038/s41564-018-0290-8","title":"Pseudomonas aeruginosa quorum-sensing metabolite induces host immune cell death through cell surface lipid domain dissolution","year":2018,"lang":"en","type":"article","venue":"Nature Microbiology","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":99,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Quorum sensing; Autoinducer; Pseudomonas aeruginosa; Cell biology; Phosphatidylserine; Microbiology; Immune system; Caspase; Homoserine; Biology; Programmed cell death; Apoptosis; Chemistry; Biochemistry; Bacteria; Immunology; Membrane; Phospholipid; Virulence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000138945,0.0002014113,0.0001579883,0.00009731425,0.0001725197,0.0003334256,0.0001631467,0.0003621621,0.0009884029],"category_scores_gemma":[0.0001510493,0.0001379558,0.0002272027,0.00006867303,0.0002317479,0.000284349,0.0003937375,0.0005219986,0.0003234084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002955643,"about_ca_system_score_gemma":0.0001773015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002616539,"about_ca_topic_score_gemma":0.000465255,"domain_scores_codex":[0.9998575,0.00001946871,0.00000740604,0.00001563716,0.00005129126,0.00004874422],"domain_scores_gemma":[0.9998926,0.00002572902,0.00003038039,0.00001760165,0.00001396764,0.00001969292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008185332,0.000009806359,0.0001117318,0.000008550005,0.000001937746,0.00004419733,0.000005849115,0.0000173671,0.9991305,0.00008998851,0.00002044515,0.0004777816],"study_design_scores_gemma":[0.00001144978,0.00008654008,0.003789648,0.000001757418,0.000003638119,0.0001369132,0.00002387886,0.0004344561,0.9949852,0.00007622474,0.0004479252,0.000002240961],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956875,0.0006910142,0.001818147,0.0001901043,0.0000188673,0.00001429059,0.0001099105,0.0000374304,0.001432636],"genre_scores_gemma":[0.9980058,0.0001806805,0.0003974336,0.00004151333,0.000003850148,0.00000874456,0.00009025158,0.000006524947,0.001265296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009884029,"threshold_uncertainty_score":0.003306508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006072244332248618,"score_gpt":0.2293794031984766,"score_spread":0.223307158866228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}