{"id":"W2902197007","doi":"10.2147/dddt.s186614","title":"Synthesis of small peptide compounds, molecular docking, and inhibitory activity evaluation against phosphatases PTP1B and SHP2","year":2018,"lang":"en","type":"article","venue":"Drug Design Development and Therapy","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Allard Foundation","keywords":"Allosteric regulation; Biochemistry; Phosphatase; Docking (animal); Peptide; Chemistry; Enzyme; Protein tyrosine phosphatase; Active site; Tripeptide; Binding site; IC50; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006589762,0.0001979711,0.0001863064,0.00005279636,0.0001465812,0.00003664611,0.00008462472,0.00007404096,0.000005501528],"category_scores_gemma":[0.0000672749,0.0001841882,0.0000211483,0.00005738459,0.0002402142,0.00001238244,0.0000881488,0.00004657418,6.331217e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001303495,"about_ca_system_score_gemma":0.0001441504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002230494,"about_ca_topic_score_gemma":0.00001071123,"domain_scores_codex":[0.9989591,0.0001583092,0.0001838662,0.0003620643,0.0001637802,0.0001728862],"domain_scores_gemma":[0.9994527,0.0000552512,0.0001257944,0.0001788978,0.0001160315,0.00007130626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003836139,0.00009166195,0.004152095,0.00003974032,0.0001594545,0.000002958892,0.0002990276,0.000006421607,0.6842649,0.00009008947,0.0005431968,0.3099668],"study_design_scores_gemma":[0.0007767118,0.000115347,0.007507687,0.0000556743,0.00001777805,0.000004216799,0.00003099636,0.0001671666,0.9871047,0.0001301139,0.003861091,0.0002285355],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9714653,0.02601778,0.001860118,0.00004513878,0.00004054574,0.0004543668,0.00001423431,0.00001104998,0.00009150124],"genre_scores_gemma":[0.9880406,0.002416424,0.009193535,0.0001323736,0.00004705556,0.00007875981,0.00005629297,0.0000198681,0.00001503638],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3097383,"threshold_uncertainty_score":0.7510976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02409958124732044,"score_gpt":0.2497696812994889,"score_spread":0.2256701000521684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}