{"id":"W2902248289","doi":"","title":"Safety, tolerability, pharmacokinetic and escalating single doses of PCK3145 in patients with metastatic hormone resistant prostatic cancer (HRPC)","year":2004,"lang":"en","type":"article","venue":"Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Tolerability; Pharmacokinetics; Prostate cancer; Medicine; In vivo; Toxicity; Cancer; Internal medicine; Pharmacology; Therapeutic index; Oncology; Prostate; Hormone; Adverse effect; Gastroenterology; Biology; Drug","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007777384,0.0004827853,0.001027339,0.0002567302,0.0002836394,0.0004548541,0.0003453681,0.0004114235,0.001074544],"category_scores_gemma":[0.0008802426,0.0002875688,0.0005570055,0.0004153255,0.0004761738,0.0004214275,0.0001937777,0.001137169,0.0002832054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005620249,"about_ca_system_score_gemma":0.0006627085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006213842,"about_ca_topic_score_gemma":0.001465648,"domain_scores_codex":[0.9995736,0.0001923539,0.00002810385,0.00006483793,0.00008345268,0.00005761335],"domain_scores_gemma":[0.99943,0.00011546,0.0001920396,0.00005139014,0.00003106755,0.0001799814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4021395,0.03655908,0.08916172,0.0008012694,0.001076138,0.000778058,0.0008637068,0.007918847,0.1862318,0.00019278,0.001729837,0.2725472],"study_design_scores_gemma":[0.03567448,0.7734055,0.1639751,0.0000343916,0.0004581812,0.001217063,0.0001402243,0.002875409,0.01951458,0.0001295645,0.002531538,0.00004400595],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998774,0.0005819799,0.0001417602,0.00004015625,0.000006036246,0.0001325302,0.0000763041,0.00001732827,0.0002297488],"genre_scores_gemma":[0.9989279,0.0002730626,0.0003045655,0.00004645472,0.00001810467,0.00008481614,0.000136526,0.000004079815,0.0002045063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001074544,"threshold_uncertainty_score":0.004113138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06460426671474814,"score_gpt":0.39543610236139,"score_spread":0.3308318356466419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}