{"id":"W2902268376","doi":"10.4155/bio-2018-0287","title":"2018 White Paper on Recent Issues in Bioanalysis: Focus on Flow Cytometry, Gene Therapy, Cut Points and Key Clarifications on Bav (Part 3 – Lba/Cell-Based Assays: Immunogenicity, Biomarkers and Pk Assays)","year":2018,"lang":"en","type":"review","venue":"Bioanalysis","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada; Caprion (Canada)","funders":"","keywords":"Bioanalysis; Immunogenicity; Biopharmaceutical; Computer science; Nanotechnology; Computational biology; Medicine; Biotechnology; Biology; Immune system; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01119596,0.001610899,0.001397945,0.00239236,0.002338634,0.009956521,0.002496614,0.009509393,0.0465921],"category_scores_gemma":[0.01974756,0.0006699842,0.001322387,0.001915487,0.002560484,0.00636332,0.002870905,0.009725444,0.04614342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004228952,"about_ca_system_score_gemma":0.007468589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001873233,"about_ca_topic_score_gemma":0.002923466,"domain_scores_codex":[0.9913936,0.001087024,0.0007171583,0.001151512,0.004898049,0.0007526313],"domain_scores_gemma":[0.9732992,0.00602085,0.002059308,0.001044455,0.01434328,0.003232812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000297799,0.00002157784,0.00004296168,0.0001995125,0.000003662673,0.00005720922,0.00005254742,0.00004666863,0.0007891711,0.003252696,0.9665653,0.02893895],"study_design_scores_gemma":[0.000002959129,0.00001405235,0.00007837793,0.0001551852,0.00000240041,0.00003426257,0.00003248577,0.00003021099,0.0003889891,0.001002511,0.9982525,0.000006015301],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"review","genre_scores_codex":[0.0008731832,0.04313498,0.009676994,0.2245586,0.6436446,0.000359888,0.001210187,0.0009996322,0.07554196],"genre_scores_gemma":[0.007471478,0.05375568,0.01081166,0.1521687,0.2779301,0.0006625179,0.003096728,0.002213528,0.4918896],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.0465921,"threshold_uncertainty_score":0.1558661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05972015392823208,"score_gpt":0.3313494038468652,"score_spread":0.2716292499186331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}