{"id":"W2902268376","doi":"10.4155/bio-2018-0287","title":"2018 White Paper on Recent Issues in Bioanalysis: Focus on Flow Cytometry, Gene Therapy, Cut Points and Key Clarifications on Bav (Part 3 – Lba/Cell-Based Assays: Immunogenicity, Biomarkers and Pk Assays)","year":2018,"lang":"en","type":"review","venue":"Bioanalysis","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada; Caprion (Canada)","funders":"","keywords":"Bioanalysis; Immunogenicity; Biopharmaceutical; Computer science; Nanotechnology; Computational biology; Medicine; Biotechnology; Biology; Immune system; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.003154509,0.001440287,0.003744205,0.00281481,0.0004711476,0.0002111829,0.000865345,0.002333444,0.002021877],"category_scores_gemma":[0.0004146079,0.001032671,0.001449948,0.00326906,0.001020525,0.00009436778,0.0002229285,0.001246086,0.0004480761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003771431,"about_ca_system_score_gemma":0.000209044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002759274,"about_ca_topic_score_gemma":0.0002950596,"domain_scores_codex":[0.9909353,0.00354961,0.001894274,0.002282155,0.0003478114,0.0009908204],"domain_scores_gemma":[0.995347,0.00116406,0.0009890493,0.002057016,0.0002391647,0.0002036804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007111894,0.002317223,0.0006128269,0.000787362,0.0164829,0.0000322232,0.00007333406,0.000002488387,0.0005803661,0.000104104,0.01270807,0.9655879],"study_design_scores_gemma":[0.001462923,0.001017675,0.0002103366,0.00169742,0.00611465,0.00001344129,0.00004906752,0.00006032569,0.002421504,0.00008982942,0.9856362,0.001226649],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008345601,0.9924291,0.000103889,0.003333086,0.0004842019,0.0009354698,0.0008986948,0.00008526516,0.001646798],"genre_scores_gemma":[0.000687734,0.993125,0.002080058,0.001176707,0.000155439,0.000150532,0.0008261719,0.0001156928,0.001682638],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9729281,"threshold_uncertainty_score":0.9998347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05972015392823208,"score_gpt":0.3313494038468652,"score_spread":0.2716292499186331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}