{"id":"W2902271181","doi":"10.1056/nejmoa1800474","title":"Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing","year":2018,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":524,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Health Services and Delivery Research Programme; National Institute of Allergy and Infectious Diseases; Medical Research Council; National Key Research and Development Program of China; National University of Singapore; Seventh Framework Programme; British Columbia Centre for Disease Control; Chinese Center for Disease Control and Prevention; National Institutes of Health; Ministerio de Economía y Competitividad; Bill and Melinda Gates Foundation; European Commission; Wellcome Trust; Wellcome; National Institute for Health and Care Research","keywords":"Ethambutol; Pyrazinamide; Isoniazid; Tuberculosis; Drug resistance; Mycobacterium tuberculosis; Rifampicin; Biology; Genetics; Medicine; Antibiotics; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001665626,0.0006140972,0.0004557584,0.0006957415,0.0002635427,0.0004265082,0.0004227673,0.0005338259,0.001113439],"category_scores_gemma":[0.004898217,0.0002734626,0.0006370458,0.0005342998,0.000319875,0.0003594502,0.0002644677,0.0003760348,0.0002767839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005314765,"about_ca_system_score_gemma":0.0007682051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002914494,"about_ca_topic_score_gemma":0.002351587,"domain_scores_codex":[0.9995174,0.0002104497,0.00003035588,0.000121916,0.00007045236,0.00004940674],"domain_scores_gemma":[0.9972537,0.00185321,0.0004500926,0.0001199682,0.0002158546,0.0001071567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001154169,0.0002168707,0.568131,0.0002070489,0.0003325662,0.0004546866,0.0001353815,0.3842117,0.0162993,0.0007211125,0.0007591842,0.02737698],"study_design_scores_gemma":[0.0001541864,0.000775573,0.2142148,0.00006983303,0.000232775,0.0005254407,0.0001643984,0.7692125,0.009783884,0.003256188,0.00156337,0.00004707988],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9826325,0.0001810424,0.01473573,0.0001319354,0.00001501473,0.0000858534,0.001346061,0.00009726145,0.0007746886],"genre_scores_gemma":[0.9834609,0.0001472348,0.01408455,0.00005795925,0.000007256728,0.0000676594,0.001982779,0.00001356501,0.0001780816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002914494,"threshold_uncertainty_score":0.008808732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04542370411130422,"score_gpt":0.3268089577280843,"score_spread":0.2813852536167801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}