{"id":"W2902294412","doi":"10.1371/journal.pgen.1007817","title":"Mutations in Kinesin family member 6 reveal specific role in ependymal cell ciliogenesis and human neurological development","year":2018,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Department of Mechanical Engineering, University of Texas at Austin; National Institutes of Health; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Thailand Research Fund","keywords":"Ciliogenesis; Cilium; Biology; Ependymal Cell; Motile cilium; Zebrafish; Cell biology; Corticogenesis; Mutation; Mutant; Neuropil; Kinesin; Neural tube; Genetics; Molecular biology; Gene; Microtubule; Neuroscience; Central nervous system; Embryonic stem cell; Embryo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009124228,0.0001904438,0.000164298,0.0001020116,0.00008050842,0.00002369883,0.0001628707,0.0001547034,0.00004852093],"category_scores_gemma":[0.00002058925,0.0001936278,0.00003299863,0.0001481089,0.0001405193,0.000002181511,0.0001571401,0.00007203434,0.00002354806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000108357,"about_ca_system_score_gemma":0.00008760238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000857653,"about_ca_topic_score_gemma":0.0001378412,"domain_scores_codex":[0.9986522,0.00008471072,0.0003211526,0.0004720478,0.0001500896,0.0003198227],"domain_scores_gemma":[0.9994838,0.00001076861,0.00004974293,0.0002484714,0.00006282597,0.0001444326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004863904,0.0002827032,0.10589,0.00001597378,0.000008765101,0.00001902608,0.0001342275,0.00004489794,0.8927284,0.000003584922,0.0002828613,0.0005408961],"study_design_scores_gemma":[0.0007418109,0.0002921621,0.4820503,0.000009431906,0.00001422814,0.000007425049,0.0001159865,0.0001080326,0.5098196,0.00008795095,0.006493067,0.0002599396],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964476,0.001483747,0.00002528144,0.00003734875,0.00004744747,0.0002243321,0.00001343195,0.000008754047,0.001712031],"genre_scores_gemma":[0.9969434,0.0001067049,0.002231819,0.0002298558,0.0001560495,0.00003883292,0.00007918596,0.00002435893,0.0001898458],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3829088,"threshold_uncertainty_score":0.7895914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02141416446543908,"score_gpt":0.239942675838155,"score_spread":0.218528511372716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}