{"id":"W2902333034","doi":"10.2144/btn-2018-0123","title":"Oxford Nanopore Sequencing Enables Rapid Discovery of Single-Domain Antibodies from Phage Display Libraries","year":2018,"lang":"en","type":"article","venue":"BioTechniques","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"","keywords":"Panning (audio); Minion; Nanopore sequencing; Phage display; Computational biology; Biology; Single-domain antibody; Genomic library; Massive parallel sequencing; DNA sequencing; Genetics; Antibody Repertoire; Antibody; Gene; Base sequence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002017684,0.000263365,0.0005151807,0.0001932226,0.0001667549,0.00007941236,0.0002405283,0.0002223342,0.0003771302],"category_scores_gemma":[0.0001048657,0.0001899895,0.0001824799,0.0002369103,0.001072536,0.0004281769,0.0002422045,0.0002214144,0.00001384655],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006260522,"about_ca_system_score_gemma":0.0001165475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005319937,"about_ca_topic_score_gemma":0.00004132801,"domain_scores_codex":[0.9982721,0.00007877452,0.0004229643,0.0003763661,0.0004391416,0.0004106142],"domain_scores_gemma":[0.9990339,0.0001665247,0.0001455519,0.0004108012,0.0001265507,0.0001166681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004596628,0.0001475767,0.005618987,0.000211703,0.0001222482,0.00008394895,0.0007557744,1.885725e-8,0.9765602,0.003374286,0.005349687,0.007315874],"study_design_scores_gemma":[0.0002509929,0.0009809674,0.001999303,0.0005492715,0.0000349182,0.00002648968,0.000287976,0.00003296545,0.9356321,0.0038404,0.05616129,0.0002033251],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9771724,0.003698088,0.002654244,0.001479072,0.0001178856,0.0003968444,0.0002984023,0.0002480957,0.01393495],"genre_scores_gemma":[0.9591404,0.001885613,0.03518024,0.0003493903,0.000628471,0.00001426885,0.0001478534,0.00004093649,0.002612786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0508116,"threshold_uncertainty_score":0.7747547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03840901377192063,"score_gpt":0.2949599369964711,"score_spread":0.2565509232245504,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}