{"id":"W2902411536","doi":"10.3389/fimmu.2018.02825","title":"Dual-Isotope SPECT/CT Imaging of the Tuberculosis Subunit Vaccine H56/CAF01: Induction of Strong Systemic and Mucosal IgA and T-Cell Responses in Mice Upon Subcutaneous Prime and Intrapulmonary Boost Immunization","year":2018,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"H. Lundbeck A/S; Danmarks Frie Forskningsfond; University of British Columbia; Lundbeckfonden","keywords":"Medicine; Tuberculosis vaccines; Immunization; Immunology; Vaccination; Mycobacterium tuberculosis; Tuberculosis; Immune system; Virology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003150729,0.0005246049,0.0003058125,0.00037576,0.0001117096,0.0002029862,0.0002603021,0.0006433084,0.0006924632],"category_scores_gemma":[0.0001277915,0.0002627065,0.0002351932,0.0001770501,0.0003254631,0.0003226711,0.0002410022,0.0006816487,0.000238336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000204328,"about_ca_system_score_gemma":0.0002246564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005794308,"about_ca_topic_score_gemma":0.0004514518,"domain_scores_codex":[0.9998916,0.00001663107,0.00000889855,0.00002870182,0.00002407694,0.00002996338],"domain_scores_gemma":[0.9999255,0.00001073409,0.00002045987,0.000008612906,0.00001116006,0.00002340239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002129613,0.00003344749,0.0001513468,0.00002630994,0.000002922791,0.00004850587,0.00000711043,0.00006536565,0.9984989,0.00002512449,0.00003854103,0.000889399],"study_design_scores_gemma":[0.00005650814,0.001040331,0.003260758,0.000008251126,0.00003155406,0.0005862096,0.00002216084,0.002970193,0.9910787,0.00003103193,0.000904116,0.00001014834],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885206,0.001682548,0.00715725,0.0001695987,0.00003338161,0.00006642835,0.0002861006,0.0001189915,0.001965263],"genre_scores_gemma":[0.982553,0.001719047,0.01188237,0.0001353404,0.00002815754,0.0001082651,0.0005056675,0.00003675546,0.003031473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006924632,"threshold_uncertainty_score":0.002316475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008772699032849855,"score_gpt":0.2511741785788567,"score_spread":0.2424014795460069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}