{"id":"W2902453870","doi":"10.1002/cphy.c150044","title":"Modulation of Skeletal Muscle Contraction by Myosin Phosphorylation","year":2016,"lang":"en","type":"review","venue":"Comprehensive physiology","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"","keywords":"Myosin; Sarcomere; Phosphorylation; Myosin light-chain kinase; Biophysics; Actin; Skeletal muscle; Myosin head; Muscle contraction; Protein filament; Chemistry; Cell biology; Allosteric regulation; Myofilament; Biochemistry; Myocyte; Biology; Anatomy; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00005425725,0.0003400997,0.002233504,0.0001258082,0.0000625183,0.000003057143,0.00006760339,0.0003301812,0.00005583109],"category_scores_gemma":[0.0000608573,0.0002475478,0.0006504202,0.0001475018,0.0002115514,0.00005540311,0.00006876088,0.0002207219,0.00008189453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001102805,"about_ca_system_score_gemma":0.00008536171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001460472,"about_ca_topic_score_gemma":2.897902e-7,"domain_scores_codex":[0.998459,0.000181194,0.0005664027,0.0004212846,0.0001491331,0.0002230165],"domain_scores_gemma":[0.9982908,0.0003576583,0.0005564551,0.0003676259,0.0003707283,0.00005676037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003691495,0.00007733963,0.000001616377,0.004650639,0.000453016,0.000002720663,0.00003521267,9.008473e-7,0.02606704,0.00008186106,0.004145795,0.964447],"study_design_scores_gemma":[0.000622154,0.0001696978,0.00389527,0.00373146,0.0007948902,0.00003309801,0.00002077897,0.000007461851,0.00008867115,0.00009607268,0.9903247,0.0002157447],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001621916,0.99611,0.0003033412,0.00002882784,0.0006647144,0.0008347437,0.0001262386,0.00004658726,0.0002636382],"genre_scores_gemma":[0.01471252,0.9839358,0.00003520833,0.00005512983,0.0004072758,0.00007695361,0.0005566435,0.00003909614,0.0001813968],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9861789,"threshold_uncertainty_score":0.9999977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04031148803626806,"score_gpt":0.3317718827264794,"score_spread":0.2914603946902113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}