{"id":"W2902460563","doi":"10.1200/jco.18.01580","title":"Fixed Duration of Venetoclax-Rituximab in Relapsed/Refractory Chronic Lymphocytic Leukemia Eradicates Minimal Residual Disease and Prolongs Survival: Post-Treatment Follow-Up of the MURANO Phase III Study","year":2018,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":301,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Genentech; Universiteit van Amsterdam","keywords":"Venetoclax; Rituximab; Bendamustine; Medicine; Internal medicine; Minimal residual disease; Hazard ratio; Gastroenterology; Neutropenia; Refractory (planetary science); Chronic lymphocytic leukemia; Oncology; Leukemia; Chemotherapy; Lymphoma; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003593471,0.0005511527,0.001397516,0.0002066482,0.0002574236,0.0006516653,0.0005302439,0.0005957988,0.0009839953],"category_scores_gemma":[0.001585879,0.0002395516,0.001068581,0.0002487032,0.0005133829,0.0003865744,0.0002189793,0.001452608,0.0002381313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006169931,"about_ca_system_score_gemma":0.0005767698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006481885,"about_ca_topic_score_gemma":0.001885528,"domain_scores_codex":[0.9990946,0.0005834915,0.00003496191,0.00008875153,0.00008461448,0.000113607],"domain_scores_gemma":[0.9985454,0.0003658062,0.0004649846,0.000211733,0.00006091074,0.0003511502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7309656,0.01273608,0.06798893,0.0006564253,0.003098198,0.0002889714,0.0002789529,0.001647705,0.02357269,0.000242197,0.002940898,0.1555833],"study_design_scores_gemma":[0.29964,0.4620801,0.2234658,0.0001368572,0.002388545,0.0006418587,0.00008961491,0.001624259,0.003517412,0.000308867,0.006051373,0.00005538079],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961164,0.002503879,0.0001150668,0.0001045154,0.00003048222,0.0001806595,0.0002462431,0.00001487735,0.0006878038],"genre_scores_gemma":[0.9971602,0.0007624477,0.0002729826,0.0002832426,0.00008917148,0.0002369679,0.0005617186,0.000006181457,0.0006271697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003593471,"threshold_uncertainty_score":0.01900434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07805887314922061,"score_gpt":0.4367975780317877,"score_spread":0.3587387048825671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}