{"id":"W2902460563","doi":"10.1200/jco.18.01580","title":"Fixed Duration of Venetoclax-Rituximab in Relapsed/Refractory Chronic Lymphocytic Leukemia Eradicates Minimal Residual Disease and Prolongs Survival: Post-Treatment Follow-Up of the MURANO Phase III Study","year":2018,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":301,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Genentech; Universiteit van Amsterdam","keywords":"Venetoclax; Rituximab; Bendamustine; Medicine; Internal medicine; Minimal residual disease; Hazard ratio; Gastroenterology; Neutropenia; Refractory (planetary science); Chronic lymphocytic leukemia; Oncology; Leukemia; Chemotherapy; Lymphoma; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003740905,0.000251033,0.001936567,0.0002474426,0.00007206381,0.000009564206,0.0003524767,0.0003498626,0.0000819676],"category_scores_gemma":[0.005897944,0.0001555947,0.0004001611,0.0003204149,0.001258484,0.0001282724,0.00016756,0.0006178998,0.000005697756],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.03194321,"about_ca_system_score_gemma":0.1123347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001143918,"about_ca_topic_score_gemma":0.001724289,"domain_scores_codex":[0.9936304,0.001273649,0.003424868,0.0003775554,0.0008948582,0.0003986526],"domain_scores_gemma":[0.9930083,0.00296285,0.002232239,0.0005583669,0.0007899276,0.0004483789],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5912629,0.03890676,0.1891995,0.001143184,0.006654707,0.005756216,0.0122458,0.000327389,0.02956155,0.0001422788,0.002016843,0.122783],"study_design_scores_gemma":[0.5565348,0.1436321,0.2846696,0.0005452648,0.001931937,0.000320797,0.001127838,0.007314072,0.002317384,0.00008764477,0.001301091,0.0002175033],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955918,0.00124247,0.000003583225,0.000908493,0.0007902609,0.001333324,0.00001361447,0.000007815021,0.000108676],"genre_scores_gemma":[0.9981108,0.0004722024,0.000100067,0.0001227631,0.0008873806,0.00002445458,0.000005523119,0.00003043473,0.0002464123],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1225654,"threshold_uncertainty_score":0.971773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07805887314922061,"score_gpt":0.4367975780317877,"score_spread":0.3587387048825671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}