{"id":"W2902472115","doi":"10.1172/jci123366","title":"Subdominance and poor intrinsic immunogenicity limit humoral immunity targeting influenza HA stem","year":2018,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Infection and Immunity; National Health and Medical Research Council; Medical Research Council; Australian Government","keywords":"Biology; Immunogenicity; Hemagglutinin (influenza); Stem cell; Immunology; Virology; Vaccination; Immunity; Epitope; Immune system; Antibody; Antigen; Influenza vaccine; Cell biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002825543,0.0002163443,0.0001861368,0.0001320979,0.00009129207,0.0003873734,0.0001494784,0.0002417352,0.000908282],"category_scores_gemma":[0.0002753119,0.0001282398,0.0001295747,0.00004992867,0.0002395749,0.0003544478,0.0002191389,0.0004427548,0.0003340263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000129079,"about_ca_system_score_gemma":0.0001517717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001817365,"about_ca_topic_score_gemma":0.000308563,"domain_scores_codex":[0.9998702,0.00004088302,0.000008155235,0.00001616936,0.00003090946,0.00003381947],"domain_scores_gemma":[0.9998127,0.00007483116,0.00003905674,0.00001692721,0.00002386011,0.00003263443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007911235,0.00002224781,0.001776684,0.0000420219,0.000003613442,0.00002889828,0.00002066873,0.00008729715,0.9943774,0.0001542006,0.0000276641,0.003380183],"study_design_scores_gemma":[0.00003495089,0.00238194,0.03052943,0.00002927132,0.0000359396,0.001188117,0.0002341146,0.002511378,0.9575976,0.0007315054,0.004719845,0.000006065867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936503,0.001826376,0.003050364,0.00007302037,0.000008020992,0.0000238256,0.00003052203,0.00003527338,0.001302335],"genre_scores_gemma":[0.997712,0.0005129669,0.001305399,0.00006988924,0.00001202419,0.00001240911,0.00003864008,0.000006466847,0.0003302926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000908282,"threshold_uncertainty_score":0.003038526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.239440989354789,"score_gpt":0.4575142499984245,"score_spread":0.2180732606436355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}