{"id":"W2902472115","doi":"10.1172/jci123366","title":"Subdominance and poor intrinsic immunogenicity limit humoral immunity targeting influenza HA stem","year":2018,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Infection and Immunity; National Health and Medical Research Council; Medical Research Council; Australian Government","keywords":"Biology; Immunogenicity; Hemagglutinin (influenza); Stem cell; Immunology; Virology; Vaccination; Immunity; Epitope; Immune system; Antibody; Antigen; Influenza vaccine; Cell biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.005435343,0.0001732792,0.0007745869,0.0001581555,0.0002219774,0.00005222558,0.0001769264,0.0001568612,0.00002914203],"category_scores_gemma":[0.01135143,0.0001334268,0.0002132792,0.0002887413,0.00139515,0.0004379241,0.0001787295,0.00115721,0.00004509831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009125397,"about_ca_system_score_gemma":0.000449393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005162893,"about_ca_topic_score_gemma":0.000009994843,"domain_scores_codex":[0.9964009,0.0005047359,0.002007579,0.0001936998,0.0005903537,0.000302748],"domain_scores_gemma":[0.9955328,0.0009083299,0.001234116,0.0002395259,0.00171808,0.0003672253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004803924,0.0002817307,0.9120266,0.0002144344,0.0005734041,0.00009339183,0.001411057,0.000005140171,0.03300051,0.0004109373,0.006240674,0.04093819],"study_design_scores_gemma":[0.005427025,0.003245116,0.9436442,0.0006083643,0.00021038,0.0001294568,0.0004282328,0.0003656099,0.03195521,0.001381964,0.01239619,0.0002082538],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995366,0.002087259,0.00004272696,0.001578326,0.0003971578,0.0002291704,0.000002787877,0.00001794529,0.0002786129],"genre_scores_gemma":[0.9899401,0.0005916051,0.004747546,0.003116901,0.001485065,0.000001875296,0.000001481353,0.00001874529,0.00009666289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04072993,"threshold_uncertainty_score":0.9969764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.239440989354789,"score_gpt":0.4575142499984245,"score_spread":0.2180732606436355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}