{"id":"W2902476519","doi":"10.1021/acs.jmedchem.8b01621","title":"Identification of Selective Acyl Sulfonamide–Cycloalkylether Inhibitors of the Voltage-Gated Sodium Channel (Na <sub>V</sub> ) 1.7 with Potent Analgesic Activity","year":2018,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"","keywords":"Chemistry; Potency; Sodium channel; Sulfonamide; Pharmacology; Pharmacokinetics; Metabolic stability; Nav1.5; In vivo; Docking (animal); Lead compound; Analgesic; Drug discovery; Combinatorial chemistry; Stereochemistry; Biochemistry; In vitro; Sodium","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002071145,0.000498472,0.000445582,0.0001917654,0.0001512421,0.0002971491,0.0003018032,0.0001853017,0.00144451],"category_scores_gemma":[0.000189927,0.0001262424,0.0002627872,0.0001902246,0.0002508551,0.0002512606,0.0002754823,0.0005684369,0.0004344261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003573149,"about_ca_system_score_gemma":0.0005038634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005364699,"about_ca_topic_score_gemma":0.002572861,"domain_scores_codex":[0.9999101,0.00001214434,0.000007465159,0.00001310099,0.00003081233,0.00002640271],"domain_scores_gemma":[0.9999262,0.000009332498,0.00002488509,0.000006063155,0.00001911316,0.00001441882],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000529898,0.000390105,0.0007031751,0.0002354165,0.00003973957,0.0003479351,0.00009871007,0.001885194,0.9511198,0.0010979,0.0006577864,0.04289439],"study_design_scores_gemma":[0.0004612769,0.01089426,0.005331555,0.00004341091,0.0001691851,0.00161052,0.00009609212,0.00444463,0.9491441,0.0004120165,0.02734325,0.00004963339],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9754891,0.007863615,0.009397625,0.0002861019,0.00006773854,0.0004179856,0.0006065026,0.0001499976,0.00572134],"genre_scores_gemma":[0.973938,0.007745052,0.01174157,0.0001924998,0.000037108,0.0001693081,0.001322173,0.000024085,0.004830247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00144451,"threshold_uncertainty_score":0.004832387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006078781025396858,"score_gpt":0.2193583373972671,"score_spread":0.2132795563718703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}