{"id":"W2902522748","doi":"10.1002/slct.201803375","title":"Squaramide‐Based 5’‐Phosphate Replacements Bind to the DNA Repair Exonuclease SNM1A","year":2018,"lang":"en","type":"article","venue":"ChemistrySelect","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"Biotechnology and Biological Sciences Research Council; Cancer Research UK","keywords":"Exonuclease; Oligonucleotide; Phosphate; Biochemistry; Chemistry; DNA; Combinatorial chemistry; DNA polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002844336,0.0003356456,0.0001963255,0.00002068133,0.0002865103,0.00005677836,0.000622775,0.0002331458,0.0004748453],"category_scores_gemma":[0.0003264743,0.0002784787,0.0002083176,0.0002713759,0.0002201682,0.000004613824,0.000205424,0.0001625703,0.0002820342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005435297,"about_ca_system_score_gemma":0.0001721197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001135597,"about_ca_topic_score_gemma":0.000008264672,"domain_scores_codex":[0.9979893,0.00002990163,0.0003181134,0.0007987888,0.000282478,0.0005814472],"domain_scores_gemma":[0.9980676,0.00001645859,0.0001209379,0.001313649,0.0002020739,0.0002793024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002725366,0.0000757036,0.0006589783,0.00003422986,0.00006597248,0.000007003405,0.00002974885,0.00001023408,0.8878757,0.000002294,0.1103798,0.0005877484],"study_design_scores_gemma":[0.0005006818,0.0002055966,0.0001666777,0.00002124173,0.0000305065,0.00001488836,0.00003569897,0.0001364563,0.7675699,0.000007115325,0.23102,0.0002912657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852957,0.0002194542,0.0002924855,0.0005678086,0.0001892782,0.0002345474,0.00003037588,0.0001117035,0.01305861],"genre_scores_gemma":[0.988987,0.00001470666,0.0006892621,0.002522296,0.001051442,0.00006194197,0.0001619679,0.00006281793,0.006448549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1206402,"threshold_uncertainty_score":0.9999667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007846057956650745,"score_gpt":0.2452168029263236,"score_spread":0.2373707449696728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}