{"id":"W2902537979","doi":"10.1128/jvi.01896-18","title":"HDAC6 Restricts Influenza A Virus by Deacetylation of the RNA Polymerase PA Subunit","year":2018,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Fundamental Research Funds for the Central Universities; National Key Research and Development Program of China; Priority Academic Program Development of Jiangsu Higher Education Institutions; National Natural Science Foundation of China","keywords":"Biology; Virology; Polymerase; Virus; Influenza A virus; Viral replication; HDAC6; RNA polymerase; Acetylation; Viral life cycle; Antiviral drug; Transcription (linguistics); RNA; Protein subunit; Genetics; Gene; Histone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001352171,0.0003420374,0.0003122078,0.0001830165,0.000170184,0.0003695615,0.0002675139,0.0001913654,0.001355241],"category_scores_gemma":[0.0001087006,0.000123152,0.0003255988,0.0001333451,0.0002459949,0.0002014933,0.0002106853,0.000417096,0.0006116909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002393694,"about_ca_system_score_gemma":0.0002274817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004999759,"about_ca_topic_score_gemma":0.001391227,"domain_scores_codex":[0.9998941,0.00001178296,0.000008898463,0.00002145077,0.00003325133,0.00003037525],"domain_scores_gemma":[0.9999478,0.000005459698,0.00001391509,0.000006387064,0.000009381243,0.00001703691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001194477,0.00001642763,0.0006055887,0.00005111623,0.000009602268,0.0000338596,0.000006719246,0.00006554541,0.9934198,0.0001361046,0.0001407949,0.005394995],"study_design_scores_gemma":[0.00002422616,0.0003106296,0.004810461,0.000006256349,0.00002529435,0.0003086653,0.00002885533,0.0008549537,0.9854912,0.0001025888,0.008032274,0.000004796059],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9657288,0.01450826,0.01006107,0.0005895546,0.0001874206,0.00007690712,0.0008491428,0.0002515198,0.007747402],"genre_scores_gemma":[0.9845462,0.005606784,0.005026951,0.000141833,0.0000513267,0.000024252,0.0006714804,0.00003470508,0.003896561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001355241,"threshold_uncertainty_score":0.004533708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01576607627722635,"score_gpt":0.2951711463230411,"score_spread":0.2794050700458147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}