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ZonMw; Hartstichting; Agence Nationale de la Recherche; Janssen Pharmaceuticals; Medtronic; University of London; King's College London; Bundesministerium für Bildung und Forschung; British Heart Foundation; National Institute for Health and Care Research; York University; National Wool Museum; Bayer Fund; Nederlandse Federatie van Universitair Medische Centra; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Actelion Pharmaceuticals; Vanderbilt University Medical Center; King's College Hospital NHS Foundation Trust; Imperial College Healthcare NHS Trust; Wellcome Trust; University of Colorado; Chiesi Farmaceutici; Utah Department of Health; Georgia Clinical and Translational Science Alliance; Cincinnati Children's Hospital Medical Center; United Therapeutics Corporation; Meso Scale Diagnostics; Columbia University; Bayer; American College of Clinical Pharmacy Research Institute; Gilead Sciences; Academy of Medical Sciences; Guy's and St Thomas' NHS Foundation Trust; National Science Foundation; California Department of Fish and Game; Deutsche Forschungsgemeinschaft; Roche; Imperial College London; GlaxoSmithKline; National Institute on Handicapped Research; American Heart Association; Eli Lilly and Company; University of Cincinnati; AstraZeneca; Pfizer; Boehringer Ingelheim; Novartis; U.S. Food and Drug Administration; New York University; U.S. Department of Veterans Affairs","keywords":"Medicine; Meta-analysis; Genome-wide association study; Pulmonary hypertension; Genetic association; Internal medicine; MEDLINE; Association (psychology); Cardiology; Environmental health; Genetics; Gene; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001967705,0.0004374311,0.006369144,0.0006833702,0.00008956705,0.000008976339,0.0003224036,0.0002249145,0.0002186357],"category_scores_gemma":[0.003593096,0.000206906,0.0007074769,0.000723905,0.0003756658,0.00004841046,0.0002041529,0.0004504018,0.00002297205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000207705,"about_ca_system_score_gemma":0.0001494533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008467393,"about_ca_topic_score_gemma":0.0001081908,"domain_scores_codex":[0.9961498,0.0008654723,0.001148559,0.0005571308,0.0008925621,0.0003864938],"domain_scores_gemma":[0.995436,0.002230639,0.0009698793,0.0008028234,0.0004115055,0.0001491604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001474564,0.0009377805,0.1413919,0.01322078,0.6471138,0.01220381,0.0004863092,0.000002461309,0.00001895356,0.000004334489,0.01442073,0.1687246],"study_design_scores_gemma":[0.001595464,0.0004092681,0.1073756,0.0009941064,0.4328877,0.0001673835,0.00007802133,0.00002035739,0.000001156097,0.00007761249,0.4561644,0.0002288962],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01179473,0.9860076,8.571266e-7,0.0009188698,0.0001988461,0.0007917616,0.0001402107,0.00001631867,0.000130769],"genre_scores_gemma":[0.003756274,0.9935777,0.00007006257,0.000913998,0.001175188,0.0001400044,0.0000575403,0.00003242777,0.0002768358],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4417437,"threshold_uncertainty_score":0.843738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2405579364248856,"score_gpt":0.4146220215679697,"score_spread":0.1740640851430841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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