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ZonMw; Hartstichting; Agence Nationale de la Recherche; Janssen Pharmaceuticals; Medtronic; University of London; King's College London; Bundesministerium für Bildung und Forschung; British Heart Foundation; National Institute for Health and Care Research; York University; National Wool Museum; Bayer Fund; Nederlandse Federatie van Universitair Medische Centra; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Actelion Pharmaceuticals; Vanderbilt University Medical Center; King's College Hospital NHS Foundation Trust; Imperial College Healthcare NHS Trust; Wellcome Trust; University of Colorado; Chiesi Farmaceutici; Utah Department of Health; Georgia Clinical and Translational Science Alliance; Cincinnati Children's Hospital Medical Center; United Therapeutics Corporation; Meso Scale Diagnostics; Columbia University; Bayer; American College of Clinical Pharmacy Research Institute; Gilead Sciences; Academy of Medical Sciences; Guy's and St Thomas' NHS Foundation Trust; National Science Foundation; California Department of Fish and Game; Deutsche Forschungsgemeinschaft; Roche; Imperial College London; GlaxoSmithKline; National Institute on Handicapped Research; American Heart Association; Eli Lilly and Company; University of Cincinnati; AstraZeneca; Pfizer; Boehringer Ingelheim; Novartis; U.S. Food and Drug Administration; New York University; U.S. Department of Veterans Affairs","keywords":"Medicine; Meta-analysis; Genome-wide association study; Pulmonary hypertension; Genetic association; Internal medicine; MEDLINE; Association (psychology); Cardiology; Environmental health; Genetics; Gene; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01593616,0.002963135,0.007429006,0.005378383,0.0008649008,0.003078924,0.002274415,0.002185962,0.004100274],"category_scores_gemma":[0.01824984,0.001344495,0.03405284,0.0109755,0.0006720313,0.001201288,0.002045083,0.003225347,0.0003950011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001083591,"about_ca_system_score_gemma":0.001178008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00621812,"about_ca_topic_score_gemma":0.005528321,"domain_scores_codex":[0.9900271,0.004926126,0.001298678,0.002303457,0.0008745894,0.0005700043],"domain_scores_gemma":[0.9881302,0.007083005,0.001529598,0.002016932,0.0008337582,0.0004065425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.005134208,0.00004807459,0.1022744,0.005183067,0.875145,0.0003069987,0.00007212764,0.002367362,0.0005675402,0.0001846501,0.00129387,0.007422762],"study_design_scores_gemma":[0.0007836549,0.0002034299,0.05305554,0.0007326995,0.9404241,0.000261007,0.00007194805,0.002538692,0.0002762126,0.0005476305,0.001068896,0.000036138],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2888477,0.6743661,0.02254665,0.002554082,0.001083395,0.000427288,0.006832333,0.0007613761,0.002581049],"genre_scores_gemma":[0.9405545,0.04776401,0.006143854,0.0007427728,0.0003961988,0.0005247852,0.003031493,0.0001910321,0.0006512672],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01593616,"threshold_uncertainty_score":0.08427954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2405579364248856,"score_gpt":0.4146220215679697,"score_spread":0.1740640851430841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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