{"id":"W2902649075","doi":"10.1038/s42255-018-0007-6","title":"Interaction between hormone-sensitive lipase and ChREBP in fat cells controls insulin sensitivity","year":2018,"lang":"en","type":"article","venue":"Nature Metabolism","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"AstraZeneca France; AstraZeneca; Agence Nationale de la Recherche; Institut Universitaire de France; British Heart Foundation; Conseil Régional Midi-Pyrénées; Novo Nordisk Fonden; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Medical Research Council; European Federation of Pharmaceutical Industries and Associations","keywords":"Lipase; Insulin sensitivity; Internal medicine; Endocrinology; Hormone-sensitive lipase; Insulin; Sensitivity (control systems); Hormone; Chemistry; Adipose tissue; Medicine; Insulin resistance; Lipolysis; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003073042,0.0002752185,0.0003900595,0.000424807,0.0003390156,0.001186658,0.0005668208,0.0003903236,0.003473731],"category_scores_gemma":[0.000444135,0.000428414,0.000422244,0.0002553244,0.0005008581,0.0005963015,0.0007913384,0.000805345,0.001234762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000802457,"about_ca_system_score_gemma":0.0002474543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006928454,"about_ca_topic_score_gemma":0.0009500548,"domain_scores_codex":[0.9997314,0.0000432007,0.00001997015,0.000090149,0.00004822586,0.00006702091],"domain_scores_gemma":[0.99972,0.00006886876,0.00004399197,0.00005568961,0.00003094803,0.00008043407],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006856021,0.00002038255,0.000522137,0.00002000529,0.000009891839,0.00006336621,0.00002146369,0.0001079954,0.9968269,0.0003754371,0.00009768846,0.001249036],"study_design_scores_gemma":[0.0001247347,0.0001455149,0.02972013,0.00001342466,0.00003485745,0.0002488513,0.0001820323,0.005539179,0.9591669,0.0008718853,0.003919215,0.00003330467],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854679,0.002491536,0.007806918,0.0006452709,0.0001937517,0.00001317632,0.0004311322,0.0003117482,0.002638625],"genre_scores_gemma":[0.9926964,0.0004156856,0.001186425,0.0001057083,0.00002562027,0.00001420727,0.00037538,0.0001052544,0.005075407],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003473731,"threshold_uncertainty_score":0.01162076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005882368867081773,"score_gpt":0.2456215801594871,"score_spread":0.2397392112924054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}