{"id":"W2902669226","doi":"10.3791/58748","title":"Effect of Fluorescent Proteins on Fusion Partners Using Polyglutamine Toxicity Assays in Yeast","year":2018,"lang":"en","type":"article","venue":"Journal of Visualized Experiments","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Schulich School of Medicine and Dentistry; Canadian Institutes of Health Research; Schulich School of Medicine and Dentistry, Western University; ALS Society of Canada","keywords":"Huntingtin; Green fluorescent protein; Fusion protein; Saccharomyces cerevisiae; Huntingtin Protein; Fluorescence; Yeast; Cell biology; Biology; Fluorescent protein; Fusion; Cell fusion; Bimolecular fluorescence complementation; Biochemistry; Computational biology; Chemistry; Cell; Gene; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007691797,0.001125963,0.000679745,0.000617489,0.0003663544,0.0007427594,0.0007613487,0.0008359768,0.0006813159],"category_scores_gemma":[0.000506515,0.0003897649,0.0006920215,0.0007404989,0.0005100204,0.0004641213,0.0009741872,0.001084465,0.0004219796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008853741,"about_ca_system_score_gemma":0.0003448047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004925003,"about_ca_topic_score_gemma":0.003783949,"domain_scores_codex":[0.9988446,0.0002410499,0.0002397129,0.0001739003,0.0003907804,0.0001098659],"domain_scores_gemma":[0.9992539,0.0002263257,0.0001936688,0.0001034807,0.0001254094,0.00009707643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007330396,0.00005799844,0.0001318767,0.00005627635,0.00001152145,0.00007774768,0.00007764818,0.000190699,0.998148,0.0001174758,0.0000311653,0.001026274],"study_design_scores_gemma":[0.000007145281,0.0002180169,0.0006126611,0.000008584254,0.00001167019,0.00008314278,0.00003339277,0.0007421804,0.9977022,0.00003221228,0.0005393034,0.000009635147],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9736866,0.002026296,0.02010072,0.0001526456,0.0000799106,0.0002142279,0.001185938,0.0003921384,0.002161614],"genre_scores_gemma":[0.9632699,0.003396546,0.02659907,0.0001321765,0.00001765018,0.0002301656,0.002106896,0.0002951746,0.003952335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004925003,"threshold_uncertainty_score":0.009792686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05811624733652874,"score_gpt":0.4554386363573117,"score_spread":0.397322389020783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}