{"id":"W2902717642","doi":"10.1161/hypertensionaha.118.12084","title":"GRP78 (Glucose-Regulated Protein of 78 kDa) Promotes Cardiomyocyte Growth Through Activation of GATA4 (GATA-Binding Protein 4)","year":2019,"lang":"en","type":"article","venue":"Hypertension","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; St. Joseph’s Healthcare Hamilton","funders":"National Heart, Lung, and Blood Institute","keywords":"GATA4; Glucose-regulated protein; Endoplasmic reticulum; Internal medicine; Pressure overload; Unfolded protein response; Muscle hypertrophy; Endocrinology; Myocyte; Cardiac myocyte; Cell biology; Biology; Transcription factor; Medicine; Biochemistry; Cardiac hypertrophy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007107787,0.0003850956,0.0001856034,0.0001701144,0.0001015444,0.0001158076,0.0001272791,0.0001363531,0.001376696],"category_scores_gemma":[0.00005265016,0.00008103647,0.0001633438,0.0000892161,0.0001775256,0.0001068472,0.0002264467,0.0003041673,0.0003531442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001743158,"about_ca_system_score_gemma":0.0001004178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002064951,"about_ca_topic_score_gemma":0.0002896343,"domain_scores_codex":[0.9999313,0.00001222916,0.000003933132,0.00001528699,0.00001850593,0.00001878842],"domain_scores_gemma":[0.999956,0.000003542106,0.00001243423,0.000003586889,0.000004521135,0.0000198735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003254433,0.000006228443,0.00007934262,0.00001255214,0.000001640816,0.00002186084,0.000002768973,0.00001276578,0.9992443,0.00003211849,0.00001851602,0.0005353725],"study_design_scores_gemma":[0.00001910386,0.0001973787,0.01092248,0.000005723135,0.0000138111,0.0002650722,0.00001805484,0.0005577368,0.9854636,0.00008515447,0.002447645,0.000004159732],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905322,0.002289521,0.004257938,0.0002126055,0.0000567076,0.00002228883,0.0003487311,0.0001893319,0.002090745],"genre_scores_gemma":[0.991683,0.001538779,0.003097703,0.00006267589,0.00002103855,0.0000269022,0.0003872817,0.00003121647,0.003151486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001376696,"threshold_uncertainty_score":0.004605472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01125648833992373,"score_gpt":0.2155028422237778,"score_spread":0.2042463538838541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}